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Tbio
CCDC28B
Coiled-coil domain-containing protein 28B

Protein Summary
Description
Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex. The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373602
  • ENSP00000362704
  • ENSG00000160050
  • ENST00000421922
  • ENSP00000413017
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
transcription factor
0.7
tissue
0.59
transcription factor binding site profile
0.56
cell line
0.51


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999992734
p_ni:  0.000007019
p_wrong:  2.47e-7
Data Source:  BioPlex
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
p_int:  0.99987167
p_ni:  0.00007549
p_wrong:  0.00005284
Data Source:  BioPlex
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
p_int:  0.931968792
p_ni:  0.068031208
Score:  0.622
Data Source:  BioPlex,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.840388565
p_ni:  0.000035099
p_wrong:  0.159576336
Score:  0.181
Data Source:  BioPlex,STRINGDB
BBS4
Tbio
Novelty:  0.01825873
Score:  0.794
Data Source:  STRINGDB
BBS1
Tbio
Novelty:  0.00939439
Score:  0.793
Data Source:  STRINGDB
MKKS
Tbio
Novelty:  0.00805347
Score:  0.778
Data Source:  STRINGDB
TTC8
Tbio
Novelty:  0.08520636
Score:  0.706
Data Source:  STRINGDB
BBS10
Tbio
Novelty:  0.03343798
Score:  0.703
Data Source:  STRINGDB
BBS5
Tbio
Novelty:  0.04208041
Score:  0.692
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 28B
VGNC:468
456711
Macaque
coiled-coil domain containing 28B
707005
Mouse
MGI:1913514
66264
Rat
RGD:1583447
682445
Dog
coiled-coil domain containing 28B
VGNC:38831
487312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 28B
Macaque
coiled-coil domain containing 28B
Mouse
Rat
Dog
coiled-coil domain containing 28B
Publication Statistics
PubMed Score 7.01
PubMed score by year
PubTator Score 2.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title