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Tbio
CCDC22
Coiled-coil domain-containing protein 22

Protein Summary
Description
Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of ac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376227
  • ENSP00000365401
  • ENSG00000101997

Symbol
  • CXorf37
  • JM1
  • RTSC2
  • CXorf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
histone modification site profile
0.7
phenotype
0.67
tissue sample
0.65
cell type or tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.42   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.42   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (250)
COMMD2
Tdark
Novelty:  0.62195903
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  1
Score:  0.993
Data Source:  BioPlex,STRINGDB
COMMD3
Tbio
Novelty:  0.07399068
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
FAM45A
Tdark
Novelty:  0.94034891
p_int:  1
Score:  0.817
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.999999999
p_ni:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.999999999
p_ni:  1e-9
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
MTMR2
Tbio
Family:  Enzyme
Novelty:  0.01403122
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
COMMD4
Tbio
Novelty:  0.20453574
p_int:  0.999999991
p_ni:  9e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
VPS33B
Tbio
Novelty:  0.02221093
p_int:  0.999999974
p_ni:  2.2e-8
p_wrong:  4e-9
Score:  0.715
Data Source:  BioPlex,STRINGDB
VIPAS39
Tbio
Novelty:  0.02348642
p_int:  0.999998229
p_ni:  2.5e-8
p_wrong:  0.000001746
Score:  0.377
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.1
childhood onset asthma
1
1
0
1
38.2
mean platelet volume
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.1
childhood onset asthma
0
1
38.2
mean platelet volume
1
13.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 22
713063
Mouse
MGI:1859608
54638
Rat
RGD:1560910
317381
Dog
coiled-coil domain containing 22
VGNC:38828
491875
Horse
coiled-coil domain containing 22
VGNC:16155
100052164
Species
Name
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 22
Mouse
Rat
Dog
coiled-coil domain containing 22
Horse
coiled-coil domain containing 22
Publication Statistics
PubMed Score 74.42
PubMed score by year
PubTator Score 18.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title