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Tdark
CCDC14
Coiled-coil domain-containing protein 14

Protein Summary
Description
Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433542
  • ENSP00000395706
  • ENSG00000175455
  • ENST00000485727
  • ENSP00000418002
  • ENST00000488653
  • ENSP00000420180
  • ENST00000489746
  • ENSP00000418403
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
cell line
0.7
transcription factor binding site profile
0.62
microRNA
0.61
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.38   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.38   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999999769
p_ni:  2.31e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.999999451
p_ni:  5.49e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999999329
p_ni:  6.56e-7
p_wrong:  1.5e-8
Score:  0.168
Data Source:  BioPlex,STRINGDB
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999952963
p_ni:  0.000047034
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.998901821
p_ni:  0.001089574
p_wrong:  0.000008605
Data Source:  BioPlex
CEP63
Tbio
Novelty:  0.08869992
Score:  0.844
Data Source:  STRINGDB
CCDC18
Tdark
Novelty:  0.61246881
Score:  0.823
Data Source:  STRINGDB
PIBF1
Tbio
Novelty:  0.0454209
Score:  0.81
Data Source:  STRINGDB
KIAA0753
Tdark
Novelty:  0.00878365
Score:  0.804
Data Source:  STRINGDB
CEP76
Tdark
Novelty:  0.3880387
Score:  0.788
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
60.2
intelligence
2
2
1
5.6
37.3
household income
2
1
2
10.5
mathematical ability
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
60.2
intelligence
1
5.6
37.3
household income
2
10.5
mathematical ability
1
6.2
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 14
VGNC:1756
746540
Macaque
coiled-coil domain containing 14
716194
Mouse
MGI:2443448
239839
Rat
RGD:1562189
288054
Dog
coiled-coil domain containing 14
VGNC:38795
608834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 14
Macaque
coiled-coil domain containing 14
Mouse
Rat
Dog
coiled-coil domain containing 14
Publication Statistics
PubMed Score 1.38
PubMed score by year
PubTator Score 0.60
PubTator score by year
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Related Publications
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PMID
Year
Title