Tdark CCDC14 Coiled-coil domain-containing protein 14

Protein Summary

Description

Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.

Uniprot Accession IDs

• Q49A88
• B7Z2Q3
• B7Z2T2
• B8ZZ41
• B8ZZ58
• D3DN98
• Q7Z3N3
• Q86T30
• Q8IWF8
• Q8WUJ8
• Q96K47
• Q9H9A3
• Q9UFH0

Gene Name

• CCDC14

Ensembl ID

• ENST00000433542
• ENSP00000395706
• ENSG00000175455
• ENST00000485727
• ENSP00000418002
• ENST00000488653
• ENSP00000420180
• ENST00000489746
• ENSP00000418403

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
cell line	0.7
transcription factor binding site profile	0.62
microRNA	0.61
tissue sample	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.38   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.38   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (65)

Explore Interacting Targets

1 – 10 of 65

• See Interactions on String-DB

CCDC183

Tdark

Novelty:  1.55719016

p_int:  0.999999769

p_ni:  2.31e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

MAGEA1

Tbio

Novelty:  0.00506874

p_int:  0.999999451

p_ni:  5.49e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

MED4

Tbio

Family:  Enzyme

Novelty:  0.01200585

p_int:  0.999999329

p_ni:  6.56e-7

p_wrong:  1.5e-8

Score:  0.168

Data Source:  BioPlex,STRINGDB

JPH4

Tbio

Novelty:  0.07699598

p_int:  0.999952963

p_ni:  0.000047034

p_wrong:  3e-9

Score:  0.181

Data Source:  BioPlex,STRINGDB

S100A4

Tchem

Novelty:  0.00136919

p_int:  0.998901821

p_ni:  0.001089574

p_wrong:  0.000008605

Data Source:  BioPlex

CEP63

Tbio

Novelty:  0.08869992

Score:  0.844

Data Source:  STRINGDB

CCDC18

Tdark

Novelty:  0.61246881

Score:  0.823

Data Source:  STRINGDB

PIBF1

Tbio

Novelty:  0.0454209

Score:  0.81

Data Source:  STRINGDB

KIAA0753

Tdark

Novelty:  0.00878365

Score:  0.804

Data Source:  STRINGDB

CEP76

Tdark

Novelty:  0.3880387

Score:  0.788

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Components (2)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
centriolar satellite	Inferred from Direct Assay (IDA)	UniProtKB
centrosome	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	1	1		60.2
intelligence	EFO_0004337	2	2	1	5.6	37.3
household income	EFO_0009695	2	1	2		10.5
mathematical ability	EFO_0004875	1	1	1		6.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		60.2
intelligence	EFO_0004337	1	5.6	37.3
household income	EFO_0009695	2		10.5
mathematical ability	EFO_0004875	1		6.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
household income
intelligence
mathematical ability
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	coiled-coil domain containing 14	VGNC:1756	746540
Macaque	coiled-coil domain containing 14		716194
Mouse	coiled-coil domain containing 14	MGI:2443448	239839
Rat	coiled-coil domain containing 14	RGD:1562189	288054
Dog	coiled-coil domain containing 14	VGNC:38795	608834

Species	Name	OMA	EggNOG	Inparanoid
Chimp	coiled-coil domain containing 14
Macaque	coiled-coil domain containing 14
Mouse	coiled-coil domain containing 14
Rat	coiled-coil domain containing 14
Dog	coiled-coil domain containing 14

Publication Statistics

PubMed Score 1.38

PubMed score by year

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PubTator Score 0.60

PubTator score by year

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Related Publications

Text Mined References (15)

Items per page:

10

0 of 0

PMID	Year	Title