You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
CCDC137
Coiled-coil domain-containing protein 137

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329214
  • ENSP00000329360
  • ENSG00000185298
  • ENST00000575223
  • ENSP00000458884

Symbol
  • cPERP-B
  • RaRF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
ligand (protein) perturbation
0.83
microRNA
0.68
tissue sample
0.68
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.3   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.986083961
p_ni:  0.013916039
Data Source:  BioPlex
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.971911154
p_ni:  0.028088846
Score:  0.54
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.964321339
p_ni:  0.035678661
Score:  0.315
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.948642725
p_ni:  0.051357275
Data Source:  BioPlex
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.943322269
p_ni:  0.056677731
Score:  0.161
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.939412127
p_ni:  0.060587873
Data Source:  BioPlex
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.916591382
p_ni:  0.083408618
Data Source:  BioPlex
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.901204309
p_ni:  0.09879568
p_wrong:  1.1e-8
Data Source:  BioPlex
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.889067095
p_ni:  0.110932905
Score:  0.412
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.886122415
p_ni:  0.113877585
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
3
3
0
1.1
98
Myopia
3
3
0
1.2
92.7
refractive error
2
2
1
5.9
88.3
ganglion cell inner plexiform layer thickness measurement
1
1
1
87.4
optic disc size measurement
1
1
1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
98
Myopia
0
1.2
92.7
refractive error
1
5.9
88.3
ganglion cell inner plexiform layer thickness measurement
1
87.4
optic disc size measurement
1
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 137
VGNC:12041
454964
Macaque
coiled-coil domain containing 137
714277
Mouse
MGI:1914541
67291
Rat
RGD:1591129
688298
Dog
coiled-coil domain containing 137
VGNC:38793
608071
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 137
Macaque
coiled-coil domain containing 137
Mouse
Rat
Dog
coiled-coil domain containing 137
Publication Statistics
PubMed Score 2.30
PubMed score by year
PubTator Score 1.97
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title