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Tbio
CCDC136
Coiled-coil domain-containing protein 136

Protein Summary
Description
May play a role in acrosome formation in spermatogenesis and in fertilization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297788
  • ENSP00000297788
  • ENSG00000128596
  • ENST00000378685
  • ENSP00000367956

Symbol
  • KIAA1793
  • NAG6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue
0.66
histone modification site profile
0.64
cellular component
0.61
tissue sample
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999999877
p_ni:  1.2e-7
p_wrong:  3e-9
Data Source:  BioPlex
GCC2
Tbio
Novelty:  0.03809539
p_int:  0.999996515
p_ni:  0.000003485
Score:  0.564
Data Source:  BioPlex,STRINGDB
CCDC77
Tdark
Novelty:  2.54727442
p_int:  0.999995966
p_ni:  0.000002411
p_wrong:  0.000001623
Score:  0.188
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999989693
p_ni:  0.000007507
p_wrong:  0.000002799
Data Source:  BioPlex
COG5
Tbio
Novelty:  0.04017657
p_int:  0.999989259
p_ni:  0.000010741
Data Source:  BioPlex
ZNF197
Tdark
Family:  TF
Novelty:  0.30062428
p_int:  0.999978136
p_ni:  0.000021842
p_wrong:  2.2e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999873216
p_ni:  0.000125305
p_wrong:  0.00000148
Data Source:  BioPlex
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.999868712
p_ni:  0.000131288
Score:  0.166
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.999743369
p_ni:  0.000256631
Data Source:  BioPlex
CCDC88A
Tbio
Novelty:  0.01077253
p_int:  0.999489662
p_ni:  0.000510338
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
2
4
89.8
self reported educational attainment
3
2
3
89.6
cognitive function measurement
3
1
3
75.4
electrocardiography
1
1
5
55.2
1
1
0
1.2
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
89.8
self reported educational attainment
3
89.6
cognitive function measurement
3
75.4
electrocardiography
5
55.2
0
1.2
51.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 136
VGNC:4300
463708
Macaque
coiled-coil domain containing 136
701874
Mouse
MGI:1918128
232664
Rat
RGD:1564459
362331
Dog
coiled-coil domain containing 136
VGNC:38792
100686370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 136
Macaque
coiled-coil domain containing 136
Mouse
Rat
Dog
coiled-coil domain containing 136
Publication Statistics
PubMed Score 11.68
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
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PMID
Year
Title