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Tdark
CCDC122
Coiled-coil domain-containing protein 122

Protein Summary
Description
This gene encodes a protein that contains a coiled-coil domain. Naturally occurring mutations in this gene are associated with leprosy. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000444614
  • ENSP00000407763
  • ENSG00000151773
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
tissue sample
0.72
trait
0.46
tissue
0.45
transcription factor binding site profile
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Data Source:  BioPlex
CCDC172
Tdark
Novelty:  4.18978102
p_int:  0.999998866
p_ni:  9.81e-7
p_wrong:  1.53e-7
Score:  0.334
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999997981
p_ni:  0.000002003
p_wrong:  1.6e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999934901
p_ni:  0.000011671
p_wrong:  0.000053428
Score:  0.185
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.842624836
p_ni:  0.000010815
p_wrong:  0.157364349
Data Source:  BioPlex
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
Score:  0.846
Data Source:  STRINGDB
TNFSF15
Tbio
Novelty:  0.00225303
Score:  0.66
Data Source:  STRINGDB
RIPK2
Tchem
Family:  Kinase
Novelty:  0.00574043
Score:  0.658
Data Source:  STRINGDB
SPRYD7
Tdark
Novelty:  0.25334319
Score:  0.624
Data Source:  STRINGDB
HDDC3
Tbio
Family:  Enzyme
Novelty:  0.03421685
Score:  0.575
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.6
89.5
3
1
0
1.2
73.9
1
1
0
1.1
65.3
2
1
0
1.1
40.7
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
89.5
0
1.2
73.9
0
1.1
65.3
0
1.1
40.7
0
1.1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 122
VGNC:14507
452568
Macaque
coiled-coil domain containing 122
704385
Mouse
MGI:1918358
108811
Rat
RGD:2321506
100360752
Dog
coiled-coil domain containing 122
485460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 122
Macaque
coiled-coil domain containing 122
Mouse
Rat
Dog
coiled-coil domain containing 122
Publication Statistics
PubMed Score 2.13
PubMed score by year
PubTator Score 2.50
PubTator score by year
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Related Publications
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PMID
Year
Title