You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CCDC120
Coiled-coil domain-containing protein 120

Protein Summary
Description
Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells (PubMed:28422092). Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly (PubMed:28422092). Recruits NIN and CEP170 to centrosomes (PubMed:28422092). Also required for neurite growth. Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth. This gene encodes a protein that contains a coiled-coil domain. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000496529
  • ENSP00000474761
  • ENSG00000147144
  • ENST00000536628
  • ENSP00000443351
  • ENST00000597275
  • ENSP00000470294
  • ENST00000603986
  • ENSP00000474071
  • ENST00000606812
  • ENSP00000475676

Symbol
  • JM11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.67
cell line
0.61
cell type or tissue
0.58
kinase perturbation
0.54
transcription factor
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.24   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CYTH4
Tbio
Novelty:  0.05783135
p_int:  0.999999993
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.171
Data Source:  BioPlex,STRINGDB
SDCCAG8
Tbio
Novelty:  0.0431837
p_int:  0.999999919
p_ni:  7.9e-8
p_wrong:  1e-9
Data Source:  BioPlex
CYTH1
Tbio
Novelty:  0.00635156
p_int:  0.999999678
p_ni:  3.22e-7
Score:  0.225
Data Source:  BioPlex,STRINGDB
CYTH2
Tbio
Novelty:  0.03560664
p_int:  0.999999092
p_ni:  9.08e-7
Score:  0.752
Data Source:  BioPlex,STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
p_int:  0.999992351
p_ni:  0.000007626
p_wrong:  2.3e-8
Score:  0.546
Data Source:  BioPlex,STRINGDB
MORN2
Tdark
Novelty:  0.07736482
p_int:  0.999982971
p_ni:  4e-9
p_wrong:  0.000017026
Score:  0.189
Data Source:  BioPlex,STRINGDB
CYTH3
Tbio
Novelty:  0.00940752
p_int:  0.999972135
p_ni:  0.000027865
Score:  0.275
Data Source:  BioPlex,STRINGDB
INA
Tbio
Novelty:  0.00708581
p_int:  0.999968325
p_ni:  0.000031675
Data Source:  BioPlex
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.999838994
p_ni:  0.000161006
Data Source:  BioPlex
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
p_int:  0.999826113
p_ni:  0.00003277
p_wrong:  0.000141117
Score:  0.517
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
59.8
eosinophil percentage of leukocytes
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
59.8
eosinophil percentage of leukocytes
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 120
712226
Mouse
MGI:1859619
54648
Rat
RGD:1561596
317377
Dog
coiled-coil domain containing 120
VGNC:38787
491873
Horse
coiled-coil domain containing 120
VGNC:16115
100062630
Species
Name
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 120
Mouse
Rat
Dog
coiled-coil domain containing 120
Horse
coiled-coil domain containing 120
Publication Statistics
PubMed Score 2.24
PubMed score by year
PubTator Score 0.20
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title