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Tdark
CCDC12
Coiled-coil domain-containing protein 12

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425441
  • ENSP00000416263
  • ENSG00000160799
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
disease perturbation
0.83
kinase perturbation
0.71
transcription factor
0.68
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ATG5
Tbio
Novelty:  0.00081472
p_int:  0.999999802
p_ni:  1.98e-7
Score:  0.534
Data Source:  BioPlex,STRINGDB
CRNKL1
Tbio
Novelty:  0.10274174
p_int:  0.999996612
p_ni:  0.000003388
Score:  0.868
Data Source:  BioPlex,STRINGDB
NUB1
Tbio
Novelty:  0.00736082
p_int:  0.999977573
p_ni:  0.000022383
p_wrong:  4.4e-8
Score:  0.371
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999662268
p_ni:  0.000337732
Score:  0.88
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999410026
p_ni:  0.000589974
Score:  0.628
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.998693971
p_ni:  0.001306022
p_wrong:  7e-9
Score:  0.619
Data Source:  BioPlex,STRINGDB
XAB2
Tbio
Novelty:  0.04104647
p_int:  0.998475369
p_ni:  0.00152463
Score:  0.309
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.998173642
p_ni:  0.001826358
Data Source:  BioPlex
CWF19L2
Tdark
Novelty:  0.80210985
p_int:  0.995904244
p_ni:  0.004095625
p_wrong:  1.3e-7
Score:  0.459
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.995156161
p_ni:  0.004843839
Score:  0.544
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
88.7
lymphocyte count
5
2
5
87
body height
2
2
2
86.2
leukocyte count
4
3
4
83.9
high density lipoprotein cholesterol measurement
5
4
5
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
88.7
lymphocyte count
5
87
body height
2
86.2
leukocyte count
4
83.9
high density lipoprotein cholesterol measurement
5
80.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 12
VGNC:1754
460328
Macaque
coiled-coil domain containing 12
712061
Mouse
MGI:1919904
72654
Rat
RGD:1306081
363151
Dog
coiled-coil domain containing 12
VGNC:38786
484785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil domain containing 12
Macaque
coiled-coil domain containing 12
Mouse
Rat
Dog
coiled-coil domain containing 12
Publication Statistics
PubMed Score 3.28
PubMed score by year
PubTator Score 2.08
PubTator score by year
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Related Publications
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PMID
Year
Title