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Tbio
CC2D1A
Coiled-coil and C2 domain-containing protein 1A

Protein Summary
Description
Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis. This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA bindi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318003
  • ENSP00000313601
  • ENSG00000132024
  • ENST00000589606
  • ENSP00000467526

Symbol
  • AKI1
  • MRT3
  • FREUD-1
  • Freud-1/Aki1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
molecular function
0.81
cellular component
0.69
transcription factor
0.68
biological process
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.72   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.72   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
CAV1
Tbio
Novelty:  0.00035244
p_int:  0.999999818
p_ni:  1.82e-7
Data Source:  BioPlex
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.999997388
p_ni:  0.000002611
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.99999014
p_ni:  0.000005717
p_wrong:  0.000004143
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.999973509
p_ni:  0.00002647
p_wrong:  2.1e-8
Data Source:  BioPlex
CRYAB
Tchem
Novelty:  0.00464213
p_int:  0.999870657
p_ni:  0.000121434
p_wrong:  0.000007909
Score:  0.205
Data Source:  BioPlex,STRINGDB
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.99979664
p_ni:  0.000200173
p_wrong:  0.000003186
Data Source:  BioPlex
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.998667658
p_ni:  0.000585219
p_wrong:  0.000747122
Data Source:  BioPlex
CHMP4A
Tbio
Novelty:  0.01163844
Score:  0.874
Data Source:  STRINGDB
CHMP4C
Tbio
Novelty:  0.07423155
Score:  0.82
Data Source:  STRINGDB
PRSS12
Tchem
Novelty:  0.02726265
Score:  0.756
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
97
leukocyte count
2
2
2
79.3
myeloid white cell count
1
1
1
77.4
lymphocyte percentage of leukocytes
1
1
1
75.7
neutrophil percentage of leukocytes
1
1
1
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
97
leukocyte count
2
79.3
myeloid white cell count
1
77.4
lymphocyte percentage of leukocytes
1
75.7
neutrophil percentage of leukocytes
1
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil and C2 domain containing 1A
VGNC:3647
468744
Macaque
coiled-coil and C2 domain containing 1A
718483
Mouse
MGI:2384831
212139
Rat
RGD:1306108
288908
Dog
coiled-coil and C2 domain containing 1A
VGNC:38771
484911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil and C2 domain containing 1A
Macaque
coiled-coil and C2 domain containing 1A
Mouse
Rat
Dog
coiled-coil and C2 domain containing 1A
Publication Statistics
PubMed Score 63.72
PubMed score by year
PubTator Score 26.41
PubTator score by year
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Related Publications
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PMID
Year
Title