You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CBX4
E3 SUMO-protein ligase CBX4

Protein Summary
Description
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:12167701, PubMed:19636380, PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167701, PubMed:19636380, PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269397
  • ENSP00000269397
  • ENSG00000141582

Symbol
  • PC2
  • NBP16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
transcription factor perturbation
0.91
molecular function
0.86
PubMedID
0.81
transcription factor
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.91   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 426   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.91   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (22)
CHEMBL3780251
Rendered image for CHEMBL3780251
CHEMBL3939958
Rendered image for CHEMBL3939958
CHEMBL4635096
Rendered image for CHEMBL4635096
CHEMBL3889586
Rendered image for CHEMBL3889586
CHEMBL3898460
Rendered image for CHEMBL3898460
CHEMBL4640223
Rendered image for CHEMBL4640223
CHEMBL3780712
Rendered image for CHEMBL3780712
CHEMBL3972289
Rendered image for CHEMBL3972289
CHEMBL3958557
Rendered image for CHEMBL3958557
CHEMBL3942693
Rendered image for CHEMBL3942693
Protein-Protein Interactions (175)
PHC1
Tbio
Novelty:  0.01530622
p_int:  0.999999844
p_ni:  1.56e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
PCGF2
Tbio
Novelty:  0.02148755
p_int:  0.999999807
p_ni:  1.77e-7
p_wrong:  1.6e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.999882238
p_ni:  0.000117762
Score:  0.971
Data Source:  BioPlex,STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.999816683
p_ni:  0.000183317
Score:  0.964
Data Source:  BioPlex,STRINGDB
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.999662024
p_ni:  0.00033797
p_wrong:  7e-9
Score:  0.162
Data Source:  BioPlex,STRINGDB
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.998774108
p_ni:  0.001225892
Score:  0.179
Data Source:  BioPlex,STRINGDB
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.995661758
p_ni:  0.004338242
Score:  0.161
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.980600705
p_ni:  0.019360952
p_wrong:  0.000038343
Score:  0.487
Data Source:  BioPlex,STRINGDB
GADD45A
Tbio
Novelty:  0.00178533
p_int:  0.979290857
p_ni:  0.020688149
p_wrong:  0.000020995
Data Source:  BioPlex
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.823645554
p_ni:  0.176349662
p_wrong:  0.000004784
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
2
2
52
risk-taking behaviour
2
2
2
47.4
smoking status measurement
2
2
2
43.8
body mass index
2
1
2
33.1
blood protein measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
52
risk-taking behaviour
2
47.4
smoking status measurement
2
43.8
body mass index
2
33.1
blood protein measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromobox 4
VGNC:9138
744720
Macaque
chromobox 4
717683
Mouse
MGI:1195985
12418
Rat
RGD:1587243
501403
Dog
chromobox 4
608556
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromobox 4
Macaque
chromobox 4
Mouse
Rat
Dog
chromobox 4
Publication Statistics
PubMed Score 43.91
PubMed score by year
PubTator Score 249.18
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title