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Tchem
CBX2
Chromobox protein homolog 2

Protein Summary
Description
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269399
  • ENSP00000269399
  • ENSG00000173894
  • ENST00000310942
  • ENSP00000308750

Symbol
  • M33
  • CDCA6
  • SRXY5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
microRNA
0.78
protein domain
0.73
transcription factor binding site profile
0.71
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (168)
PCGF2
Tbio
Novelty:  0.02148755
p_int:  0.999999994
p_ni:  2e-9
p_wrong:  4e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
PHC1
Tbio
Novelty:  0.01530622
p_int:  0.99999999
p_ni:  6e-9
p_wrong:  4e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
RPL7
Tbio
Novelty:  0.00552644
p_int:  0.999985243
p_ni:  0.000014757
Score:  0.21
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999943786
p_ni:  0.000056213
p_wrong:  1e-9
Score:  0.238
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999484679
p_ni:  0.000509703
p_wrong:  0.000005617
Data Source:  BioPlex
L3MBTL1
Tchem
Family:  TF; Epigenetic
Novelty:  0.02321712
p_int:  0.996972942
p_ni:  0.001899011
p_wrong:  0.001128046
Score:  0.392
Data Source:  BioPlex,STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.995319121
p_ni:  0.000448951
p_wrong:  0.004231928
Data Source:  BioPlex
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
Score:  0.99
Data Source:  STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
Score:  0.989
Data Source:  STRINGDB
PHC2
Tbio
Novelty:  0.01943349
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
2
2
52
risk-taking behaviour
2
2
2
47.4
smoking status measurement
2
2
2
43.8
body mass index
2
1
2
33.1
platelet crit
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
52
risk-taking behaviour
2
47.4
smoking status measurement
2
43.8
body mass index
2
33.1
platelet crit
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88289
12416
Rat
RGD:1588561
303730
Dog
chromobox 2
VGNC:51933
483349
Horse
chromobox 2
VGNC:16098
100056959
Cow
chromobox 2
VGNC:26817
506628
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
chromobox 2
Horse
chromobox 2
Cow
chromobox 2
Publication Statistics
PubMed Score 63.87
PubMed score by year
PubTator Score 42.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title