Tbio CBR3 Carbonyl reductase [NADPH] 3

Protein Summary

Description

Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75828
• Q6FHP2

Gene Name

• CBR3

Ensembl ID

• ENST00000290354
• ENSP00000290354
• ENSG00000159231

Symbol

• hCBR3
• SDR21C2
• HEL-S-25

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
small molecule perturbation	0.81
interacting protein	0.79
kinase perturbation	0.76
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.12   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.12   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0