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Tbio
CBARP
Voltage-dependent calcium channel beta subunit-associated regulatory protein

Protein Summary
Description
Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000590083
  • ENSP00000465260
  • ENSG00000099625
  • ENST00000650044
  • ENSP00000497208

Symbol
  • C19orf26
  • DOS
  • BARP
  • C19orf26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.15   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.15   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
p_int:  0.999989452
p_ni:  0.000010547
p_wrong:  1e-9
Score:  0.808
Data Source:  BioPlex,STRINGDB
CACNB1
Tbio
Family:  IC
Novelty:  0.06568749
p_int:  0.999961336
p_ni:  0.000038664
Score:  0.823
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.990596273
p_ni:  0.009381814
p_wrong:  0.000021913
Data Source:  BioPlex
STARD3
Tbio
Novelty:  0.01540936
p_int:  0.979938297
p_ni:  0.02005983
p_wrong:  0.000001873
Score:  0.188
Data Source:  BioPlex,STRINGDB
FADS3
Tbio
Family:  Enzyme
Novelty:  0.02899077
p_int:  0.8950972
p_ni:  0.104901727
p_wrong:  0.000001073
Data Source:  BioPlex
TMC6
Tbio
Family:  IC
Novelty:  0.00761789
p_int:  0.88677513
p_ni:  0.11322487
Score:  0.379
Data Source:  BioPlex,STRINGDB
C19orf24
Tdark
Novelty:  0.72451174
Score:  0.584
Data Source:  STRINGDB
GDF9
Tbio
Novelty:  0.00258351
Score:  0.571
Data Source:  STRINGDB
BMP15
Tbio
Novelty:  0.00364888
Score:  0.55
Data Source:  STRINGDB
PIN1
Tchem
Family:  Enzyme
Novelty:  0.00957198
Score:  0.541
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
8
98.1
reticulocyte measurement
3
3
3
94.2
reticulocyte count
7
2
7
91.4
lymphocyte count
1
5
5
91.1
lymphocyte percentage of leukocytes
1
2
2
85.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
8
98.1
reticulocyte measurement
3
94.2
reticulocyte count
7
91.4
lymphocyte count
5
91.1
lymphocyte percentage of leukocytes
2
85.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CACN beta subunit associated regulatory protein
721208
Mouse
MGI:1354170
100503659
Dog
CACN subunit beta associated regulatory protein
VGNC:54587
Cow
CACN subunit beta associated regulatory protein
VGNC:26806
785529
Xenopus
calcium channel, voltage-dependent, beta subunit associated regulatory protein
XB-GENE-6258190
100124991
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CACN beta subunit associated regulatory protein
Mouse
Dog
CACN subunit beta associated regulatory protein
Cow
CACN subunit beta associated regulatory protein
Xenopus
calcium channel, voltage-dependent, beta subunit associated regulatory protein
Publication Statistics
PubMed Score 20.15
PubMed score by year
PubTator Score 17.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title