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Tbio
CAVIN4
Caveolae-associated protein 4

Protein Summary
Description
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307584
  • ENSP00000418668
  • ENSG00000170681

Symbol
  • MURC
  • MURC
  • cavin-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
TRIM54
Tbio
Novelty:  0.0198735
Score:  0.747
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.743
Data Source:  STRINGDB
SESTD1
Tbio
Novelty:  0.2052002
Score:  0.647
Data Source:  STRINGDB
DACT1
Tbio
Novelty:  0.00217915
Score:  0.643
Data Source:  STRINGDB
LRRC17
Tdark
Novelty:  0.16875862
Score:  0.623
Data Source:  STRINGDB
MYBPH
Tbio
Novelty:  0.00247863
Score:  0.614
Data Source:  STRINGDB
CAV2
Tbio
Novelty:  0.00324146
Score:  0.612
Data Source:  STRINGDB
CAV1
Tbio
Novelty:  0.00035244
Score:  0.611
Data Source:  STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.596
Data Source:  STRINGDB
SIX4
Tbio
Family:  TF
Novelty:  0.01783726
Score:  0.578
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
6.9
42.6
glomerular filtration rate
1
1
1
19.6
BMI-adjusted waist-hip ratio
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
6.9
42.6
glomerular filtration rate
1
19.6
BMI-adjusted waist-hip ratio
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caveolae associated protein 4
VGNC:48972
464620
Mouse
MGI:1915266
68016
Rat
RGD:1310395
313225
Dog
caveolae associated protein 4
VGNC:38756
481632
Horse
caveolae associated protein 4
VGNC:16090
100054653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caveolae associated protein 4
Mouse
Rat
Dog
caveolae associated protein 4
Horse
caveolae associated protein 4
Publication Statistics
PubMed Score 45.83
PubMed score by year
PubTator Score 20.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title