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Tbio
CAVIN2
Caveolae-associated protein 2

Protein Summary
Description
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304141
  • ENSP00000305675
  • ENSG00000168497

Symbol
  • SDPR
  • SDR
  • SDPR
  • PS-p68
  • cavin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.67   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.67   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
DHRS1
Tdark
Family:  Enzyme
Novelty:  0.42768299
Score:  0.904
Data Source:  STRINGDB
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
Score:  0.802
Data Source:  STRINGDB
HTATIP2
Tbio
Family:  Enzyme
Novelty:  0.01940704
Score:  0.8
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.76
Data Source:  STRINGDB
RDH8
Tbio
Family:  Enzyme
Novelty:  0.06071472
Score:  0.756
Data Source:  STRINGDB
CAV1
Tbio
Novelty:  0.00035244
Score:  0.756
Data Source:  STRINGDB
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
Score:  0.752
Data Source:  STRINGDB
DHRS4L2
Tbio
Family:  Enzyme
Novelty:  0.03296542
Score:  0.752
Data Source:  STRINGDB
RDH11
Tbio
Family:  Enzyme
Novelty:  0.02758936
Score:  0.751
Data Source:  STRINGDB
MDC1
Tbio
Novelty:  0.00533097
Score:  0.693
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
5
95.8
platelet count
2
1
2
21.2
1
1
0
1.1
1
2
1
0
1.1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
95.8
platelet count
2
21.2
0
1.1
1
0
1.1
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caveolae associated protein 2
VGNC:2811
744890
Macaque
caveolae associated protein 2
694299
Mouse
MGI:99513
20324
Rat
RGD:1359345
316384
Horse
caveolae associated protein 2
VGNC:16089
100054790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caveolae associated protein 2
Macaque
caveolae associated protein 2
Mouse
Rat
Horse
caveolae associated protein 2
Publication Statistics
PubMed Score 104.67
PubMed score by year
PubTator Score 288.80
PubTator score by year
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Related Publications
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PMID
Year
Title