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Tbio
CAV1
Caveolin-1

Protein Summary
Description
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341049
  • ENSP00000339191
  • ENSG00000105974
  • ENST00000393467
  • ENSP00000377110
  • ENST00000393468
  • ENSP00000377111
  • ENST00000405348
  • ENSP00000384348
  • ENST00000614113
  • ENSP00000479447

Symbol
  • CAV
  • CGL3
  • PPH3
  • BSCL3
  • LCCNS
  • VIP21
  • MSTP085
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
gene perturbation
0.99
PubMedID
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3372.68   (req: < 5)
Gene RIFs: 726   (req: <= 3)
Antibodies: 1107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3372.68   (req: >= 5)
Gene RIFs: 726   (req: > 3)
Antibodies: 1107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (437)
CC2D1A
Tbio
Novelty:  0.01970021
p_int:  0.999999818
p_ni:  1.82e-7
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.999975774
p_ni:  0.000024226
Data Source:  BioPlex
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
p_int:  0.999964587
p_ni:  0.000032627
p_wrong:  0.000002786
Score:  0.272
Data Source:  BioPlex,STRINGDB
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.999944682
p_ni:  0.000055318
Score:  0.217
Data Source:  BioPlex,STRINGDB
CAV3
Tbio
Novelty:  0.00190092
p_int:  0.999885841
p_ni:  0.000113977
p_wrong:  1.83e-7
Score:  0.825
Data Source:  BioPlex,STRINGDB
MSRB2
Tbio
Family:  Enzyme
Novelty:  0.00729088
p_int:  0.999885527
p_ni:  0.000114061
p_wrong:  4.12e-7
Data Source:  BioPlex
TACR1
Tclin
Family:  GPCR
Novelty:  0.00062762
p_int:  0.99960269
p_ni:  0.00039731
p_wrong:  1e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.99960071
p_ni:  0.000381592
p_wrong:  0.000017698
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.99946444
p_ni:  0.000527683
p_wrong:  0.000007877
Data Source:  BioPlex
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
p_int:  0.99583932
p_ni:  0.002136622
p_wrong:  0.002024058
Score:  0.277
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 6
EGFR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  3
FYN
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
ITGB7
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  1
Pathways (58)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Disassembly of the destruction complex and recruitment of AXIN to the membrane
ESR-mediated signaling
Extra-nuclear estrogen signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (136)
Find Similar Targets
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
0
1.1
98
intraocular pressure measurement
8
5
11
97.5
3
3
0
1.1
93.2
electrocardiography
2
2
12
6.4
92.1
PR interval
7
3
0
2.2
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98
intraocular pressure measurement
11
97.5
0
1.1
93.2
electrocardiography
12
6.4
92.1
PR interval
0
2.2
92.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caveolin 1
VGNC:4295
463670
Macaque
caveolin 1
704449
Mouse
MGI:102709
12389
Rat
RGD:2280
25404
Dog
caveolin 1
VGNC:38751
403980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caveolin 1
Macaque
caveolin 1
Mouse
Rat
Dog
caveolin 1
Publication Statistics
PubMed Score 3372.68
PubMed score by year
PubTator Score 2703.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title