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Tbio
CAV1
Caveolin-1

Protein Summary
Description
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341049
  • ENSP00000339191
  • ENSG00000105974
  • ENST00000393467
  • ENSP00000377110
  • ENST00000393468
  • ENSP00000377111
  • ENST00000405348
  • ENSP00000384348
  • ENST00000614113
  • ENSP00000479447

Symbol
  • CAV
  • CGL3
  • PPH3
  • BSCL3
  • LCCNS
  • VIP21
  • MSTP085
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
gene perturbation
0.99
PubMedID
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3630.25   (req: < 5)
Gene RIFs: 726   (req: <= 3)
Antibodies: 1107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3630.25   (req: >= 5)
Gene RIFs: 726   (req: > 3)
Antibodies: 1107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 114
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0