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Tdark
CATSPERB
Cation channel sperm-associated protein subunit beta

Protein Summary
Description
Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256343
  • ENSP00000256343
  • ENSG00000133962
  • ENST00000619027
  • ENSP00000478546
  • ENSG00000274338

Symbol
  • C14orf161
  • C14orf161
  • CatSper(beta)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
virus perturbation
0.68
cellular component
0.62
tissue sample
0.6
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.35   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.35   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
CATSPERD
Tdark
Novelty:  0.85066163
Score:  0.983
Data Source:  STRINGDB
CATSPERG
Tdark
Novelty:  0.73161601
Score:  0.982
Data Source:  STRINGDB
CATSPER1
Tchem
Family:  IC
Novelty:  0.01971564
Score:  0.981
Data Source:  Reactome,STRINGDB
CATSPER4
Tchem
Family:  IC
Novelty:  0.4554917
Score:  0.966
Data Source:  Reactome,STRINGDB
CATSPER3
Tchem
Family:  IC
Novelty:  0.09919608
Score:  0.96
Data Source:  Reactome,STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.95
Data Source:  Reactome,STRINGDB
CATSPERE
Tdark
Novelty:  0.95910237
Score:  0.929
Data Source:  STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
Score:  0.894
Data Source:  STRINGDB
CATSPERZ
Tdark
Novelty:  0.61619097
Score:  0.84
Data Source:  STRINGDB
CACNA1B
Tclin
Family:  IC
Novelty:  0.00319692
Score:  0.815
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
96
body height
1
1
1
71.5
von Willebrand factor measurement
1
1
2
71
calcium measurement
1
1
1
59
3
1
2
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
96
body height
1
71.5
von Willebrand factor measurement
2
71
calcium measurement
1
59
2
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated auxiliary subunit beta
VGNC:13041
453110
Macaque
cation channel sperm associated auxiliary subunit beta
697012
Mouse
MGI:2443988
271036
Dog
cation channel sperm associated auxiliary subunit beta
VGNC:38747
607178
Cow
cation channel sperm associated auxiliary subunit beta
VGNC:26796
617124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated auxiliary subunit beta
Macaque
cation channel sperm associated auxiliary subunit beta
Mouse
Dog
cation channel sperm associated auxiliary subunit beta
Cow
cation channel sperm associated auxiliary subunit beta
Publication Statistics
PubMed Score 1.35
PubMed score by year
PubTator Score 1.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title