Tchem CATSPER4 Cation channel sperm-associated protein 4

Protein Summary

Description

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.

Uniprot Accession IDs

• Q7RTX7
• A1A4W6
• Q5VY71
• CatSper4

Gene Name

• CATSPER4

Ensembl ID

• ENST00000456354
• ENSP00000390423
• ENSG00000188782
• ENST00000518899
• ENSP00000429464

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.81
cell type or tissue	0.67
tissue sample	0.64
cellular component	0.61
cell line	0.53

Protein Classes

DTO Classes

Protein / Ion Channel / Cation Channel Sperm-associated Family / Cation Channel Sperm-associated Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.7   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.7   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3