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Tchem
CATSPER4
Cation channel sperm-associated protein 4

Protein Summary
Description
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000456354
  • ENSP00000390423
  • ENSG00000188782
  • ENST00000518899
  • ENSP00000429464
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
cell type or tissue
0.67
tissue sample
0.64
cellular component
0.61
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.81   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.81   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (55)
TRAF4
Tbio
Novelty:  0.01317133
p_int:  0.99994854
p_ni:  0.000050961
p_wrong:  4.99e-7
Score:  0.53
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.994357075
p_ni:  0.005642925
Data Source:  BioPlex
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.873395828
p_ni:  0.126604171
p_wrong:  1e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.809307211
p_ni:  0.190692789
Score:  0.295
Data Source:  BioPlex,STRINGDB
CATSPERG
Tdark
Novelty:  0.73161601
Score:  0.968
Data Source:  Reactome,STRINGDB
CATSPERB
Tdark
Novelty:  0.69373919
Score:  0.966
Data Source:  Reactome,STRINGDB
CATSPERD
Tdark
Novelty:  0.85066163
Score:  0.965
Data Source:  Reactome,STRINGDB
CATSPER1
Tchem
Family:  IC
Novelty:  0.01971564
Score:  0.948
Data Source:  Reactome,STRINGDB
CATSPER3
Tchem
Family:  IC
Novelty:  0.09919608
Score:  0.941
Data Source:  Reactome,STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.931
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.5
eosinophil percentage of leukocytes
1
1
1
54.4
granulocyte percentage of myeloid white cells
1
1
1
49.5
BMI-adjusted waist-hip ratio
1
1
1
35
platelet crit
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.5
eosinophil percentage of leukocytes
1
54.4
granulocyte percentage of myeloid white cells
1
49.5
BMI-adjusted waist-hip ratio
1
35
platelet crit
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated 4
VGNC:10586
736458
Macaque
cation channel sperm associated 4
714205
Mouse
MGI:3043288
329954
Rat
RGD:1565213
362623
Horse
cation channel sperm associated 4
VGNC:16083
100071168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated 4
Macaque
cation channel sperm associated 4
Mouse
Rat
Horse
cation channel sperm associated 4
Publication Statistics
PubMed Score 1.81
PubMed score by year
PubTator Score 1.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title