Protein Summary
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
- ENST00000309190
- ENSP00000312523
- ENSG00000153113
- ENST00000338252
- ENSP00000343421
- ENST00000341926
- ENSP00000339914
- ENST00000395812
- ENSP00000379157
- ENST00000395813
- ENSP00000379158
- ENST00000508830
- ENSP00000425721
- ENST00000510756
- ENSP00000422176
- BS-17
- PLACK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.93 | ||
transcription factor | 0.91 | ||
trait | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 999.75 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 367 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 999.75 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 367 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (78)
CAPN1
Novelty: 0.00252811
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAPN8
Novelty: 0.03562561
p_int: 0.999999959
p_ni: 4.1e-8
Score: 0.994
Data Source: BioPlex,STRINGDB
CAPNS2
Novelty: 0.45658116
p_int: 0.999999529
p_ni: 4.71e-7
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
CAPN2
Novelty: 0.00431673
p_int: 0.999986438
p_ni: 0.000013562
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
FNTB
Family: Enzyme
Novelty: 0.07434994
p_int: 0.99973774
p_ni: 0.00026226
Score: 0.555
Data Source: BioPlex,STRINGDB
MTUS2
Novelty: 0.13504593
p_int: 0.766621556
p_ni: 0.233378368
p_wrong: 7.6e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | ||||
Reactome | Disease | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Neurodegenerative Diseases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Degradation of the extracellular matrix | ||||
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | ||||
Disease | ||||
Extracellular matrix organization | ||||
Neurodegenerative Diseases | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (5)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
3 | 4 | 0 | 1.3 | 95.9 | |||||
body mass index | 7 | 5 | 7 | 3.8 | 92.4 | ||||
4 | 3 | 0 | 1.2 | 88.8 | |||||
1 | 1 | 0 | 1.5 | 66.8 | |||||
platelet count | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.3 | 95.9 | |||||
body mass index | 7 | 3.8 | 92.4 | ||||
0 | 1.2 | 88.8 | |||||
0 | 1.5 | 66.8 | |||||
platelet count | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | calpastatin | VGNC:3930 | 462348 | |||||
Macaque | calpastatin | 703623 | ||||||
Mouse | MGI:1098236 | 12380 | ||||||
Rat | RGD:2278 | 25403 | ||||||
Dog | calpastatin | VGNC:38742 | 479148 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | calpastatin | |||||
Macaque | calpastatin | |||||
Mouse | ||||||
Rat | ||||||
Dog | calpastatin | |||||
Publication Statistics
PubMed Score 999.75
PubMed score by year
PubTator Score 234.81
PubTator score by year
Related Publications
Text Mined References (101)
GeneRif Annotations (45)
Items per page:
0 of 0
PMID | Year | Title |
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