Tbio CAST Calpastatin

Protein Summary

Description

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P20810
• B7Z468
• G5E946
• G5E9D3
• O95360
• Q05DE8
• Q7Z4K0
• Q96D08
• Q9H1Z5

Gene Name

• CAST

Ensembl ID

• ENST00000309190
• ENSP00000312523
• ENSG00000153113
• ENST00000338252
• ENSP00000343421
• ENST00000341926
• ENSP00000339914
• ENST00000395812
• ENSP00000379157
• ENST00000395813
• ENSP00000379158
• ENST00000508830
• ENSP00000425721
• ENST00000510756
• ENSP00000422176

Symbol

• BS-17
• PLACK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.97
disease perturbation	0.93
transcription factor	0.91
trait	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 999.75   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 367   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 999.75   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (78)

Explore Interacting Targets

1 – 10 of 78

• See Interactions on String-DB

CAPN1

Tchem

Novelty:  0.00252811

p_int:  0.999999996

p_ni:  4e-9

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

CAPN8

Tbio

Novelty:  0.03562561

p_int:  0.999999959

p_ni:  4.1e-8

Score:  0.994

Data Source:  BioPlex,STRINGDB

CAPNS2

Tbio

Novelty:  0.45658116

p_int:  0.999999529

p_ni:  4.71e-7

Score:  0.98

Data Source:  BioPlex,Reactome,STRINGDB

CAPN2

Tchem

Novelty:  0.00431673

p_int:  0.999986438

p_ni:  0.000013562

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

FNTB

Tclin

Family:  Enzyme

Novelty:  0.07434994

p_int:  0.99973774

p_ni:  0.00026226

Score:  0.555

Data Source:  BioPlex,STRINGDB

MTUS2

Tbio

Novelty:  0.13504593

p_int:  0.766621556

p_ni:  0.233378368

p_wrong:  7.6e-8

Score:  0.165

Data Source:  BioPlex,STRINGDB

CAPNS1

Tbio

Novelty:  0.00954566

Score:  0.982

Data Source:  Reactome,STRINGDB

CDK5

Tchem

Family:  Kinase

Novelty:  0.00071394

Score:  0.949

Data Source:  STRINGDB

CAPN9

Tbio

Novelty:  0.0431286

Score:  0.945

Data Source:  STRINGDB

CAPN6

Tbio

Novelty:  0.04489237

Score:  0.943

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Degradation of the extracellular matrix (R-HSA-1474228)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	22 targets	R-HSA-8862803
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Neurodegenerative Diseases	22 targets	R-HSA-8863678

Name	Explore in Pharos	Explore in Source
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	22 targets	R-HSA-8862803
Disease	1105 targets	R-HSA-1643685
Extracellular matrix organization	297 targets	R-HSA-1474244
Neurodegenerative Diseases	22 targets	R-HSA-8863678

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (5)

Components (3)

Processes (3)

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1 – 5 of 5

GO Term	Evidence	Assigned by
calcium-dependent cysteine-type endopeptidase inhibitor activity	Inferred from Mutant Phenotype (IMP)	CAFA
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
protease binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
endopeptidase inhibitor activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations (null)

No disease associations found

GWAS Traits (16)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ankylosing spondylitis	EFO_0003898	3	4	0	1.3	95.9
body mass index	EFO_0004340	7	5	7	3.8	92.4
psoriasis	EFO_0000676	4	3	0	1.2	88.8
anterior uveitis	EFO_1000811	1	1	0	1.5	66.8
platelet count	EFO_0004309	1	1	1		54.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
ankylosing spondylitis	EFO_0003898	0	1.3	95.9
body mass index	EFO_0004340	7	3.8	92.4
psoriasis	EFO_0000676	0	1.2	88.8
anterior uveitis	EFO_1000811	0	1.5	66.8
platelet count	EFO_0004309	1		54.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
Palmoplantar keratoderma
Phosphoprotein
Polymorphism
Protease inhibitor
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
Agents acting on the renin-angiotensin system use measurement
ankylosing spondylitis
anterior uveitis
appendicular lean mass
Behcet's syndrome
body mass index
Calcium channel blocker use measurement
diet measurement
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
integument phenotype
limbs/digits/tail phenotype
muscle phenotype
nervous system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	calpastatin	VGNC:3930	462348
Macaque	calpastatin		703623
Mouse	calpastatin	MGI:1098236	12380
Rat	calpastatin	RGD:2278	25403
Dog	calpastatin	VGNC:38742	479148

Species	Name	OMA	EggNOG	Inparanoid
Chimp	calpastatin
Macaque	calpastatin
Mouse	calpastatin
Rat	calpastatin
Dog	calpastatin

Publication Statistics

PubMed Score 999.75

PubMed score by year

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PubTator Score 234.81

PubTator score by year

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Related Publications

Text Mined References (101)

GeneRif Annotations (45)

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PMID	Year	Title