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Tbio
CAST
Calpastatin

Protein Summary
Description
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309190
  • ENSP00000312523
  • ENSG00000153113
  • ENST00000338252
  • ENSP00000343421
  • ENST00000341926
  • ENSP00000339914
  • ENST00000395812
  • ENSP00000379157
  • ENST00000395813
  • ENSP00000379158
  • ENST00000508830
  • ENSP00000425721
  • ENST00000510756
  • ENSP00000422176

Symbol
  • BS-17
  • PLACK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.97
disease perturbation
0.93
transcription factor
0.91
trait
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 999.75   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 367   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 999.75   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CAPN8
Tbio
Novelty:  0.03562561
p_int:  0.999999959
p_ni:  4.1e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
CAPNS2
Tbio
Novelty:  0.45658116
p_int:  0.999999529
p_ni:  4.71e-7
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.999986438
p_ni:  0.000013562
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.99973774
p_ni:  0.00026226
Score:  0.555
Data Source:  BioPlex,STRINGDB
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.766621556
p_ni:  0.233378368
p_wrong:  7.6e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
CAPNS1
Tbio
Novelty:  0.00954566
Score:  0.982
Data Source:  Reactome,STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
Score:  0.949
Data Source:  STRINGDB
CAPN9
Tbio
Novelty:  0.0431286
Score:  0.945
Data Source:  STRINGDB
CAPN6
Tbio
Novelty:  0.04489237
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Degradation of the extracellular matrix (R-HSA-1474228)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Disease
Reactome
Extracellular matrix organization
Reactome
Neurodegenerative Diseases
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Disease
Extracellular matrix organization
Neurodegenerative Diseases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
1.3
95.9
body mass index
7
5
7
3.8
92.4
4
3
0
1.2
88.8
1
1
0
1.5
66.8
platelet count
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
95.9
body mass index
7
3.8
92.4
0
1.2
88.8
0
1.5
66.8
platelet count
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpastatin
VGNC:3930
462348
Macaque
calpastatin
703623
Mouse
MGI:1098236
12380
Rat
RGD:2278
25403
Dog
calpastatin
VGNC:38742
479148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpastatin
Macaque
calpastatin
Mouse
Rat
Dog
calpastatin
Publication Statistics
PubMed Score 999.75
PubMed score by year
PubTator Score 234.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title