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Tbio
CASS4
Cas scaffolding protein family member 4

Protein Summary
Description
Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360314
  • ENSP00000353462
  • ENSG00000087589
  • ENST00000434344
  • ENSP00000410027

Symbol
  • C20orf32
  • HEFL
  • CAS4
  • HEFL
  • HEPL
  • C20orf32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
tissue
0.68
tissue sample
0.67
cell line
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
MICAL1
Tbio
Family:  Enzyme
Novelty:  0.02668048
p_int:  0.999366025
p_ni:  0.000633975
Score:  0.361
Data Source:  BioPlex,STRINGDB
NME8
Tbio
Novelty:  0.05439119
Score:  0.814
Data Source:  STRINGDB
ZCWPW1
Tbio
Family:  Epigenetic
Novelty:  0.11264543
Score:  0.8
Data Source:  STRINGDB
ANKS1B
Tbio
Novelty:  0.03495546
Score:  0.766
Data Source:  STRINGDB
FERMT2
Tbio
Novelty:  0.01020276
Score:  0.734
Data Source:  STRINGDB
RIN3
Tbio
Novelty:  0.07790793
Score:  0.729
Data Source:  STRINGDB
SLC24A4
Tbio
Family:  Transporter
Novelty:  0.02745216
Score:  0.705
Data Source:  STRINGDB
ABCA7
Tbio
Family:  Transporter
Novelty:  0.00808369
Score:  0.7
Data Source:  STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.685
Data Source:  STRINGDB
MS4A6A
Tbio
Novelty:  0.04742307
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
80
platelet count
2
2
2
73.8
family history of Alzheimer’s disease
1
2
0
5.9
50.6
2
2
0
5.5
50.6
mean corpuscular hemoglobin concentration
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
80
platelet count
2
73.8
family history of Alzheimer’s disease
0
5.9
50.6
0
5.5
50.6
mean corpuscular hemoglobin concentration
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cas scaffold protein family member 4
VGNC:9828
458350
Macaque
Cas scaffolding protein family member 4
697924
Mouse
MGI:2444482
320664
Rat
RGD:1310643
296409
Dog
Cas scaffold protein family member 4
VGNC:38741
477269
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cas scaffold protein family member 4
Macaque
Cas scaffolding protein family member 4
Mouse
Rat
Dog
Cas scaffold protein family member 4
Publication Statistics
PubMed Score 95.39
PubMed score by year
PubTator Score 51.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title