You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CASR
Extracellular calcium-sensing receptor

Protein Summary
Description
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). The protein encoded by this gene is a plasma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000498619
  • ENSP00000420194
  • ENSG00000036828
  • ENST00000638421
  • ENSP00000492190
  • ENST00000639785
  • ENSP00000491584

Symbol
  • GPRC2A
  • PCAR1
  • CAR
  • FHH
  • FIH
  • HHC
  • EIG8
  • HHC1
  • NSHPT
  • PCAR1
  • hCasR
  • GPRC2A
  • HYPOC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
phenotype
0.81
biological term
0.78
disease
0.68
chemical
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2028.74   (req: < 5)
Gene RIFs: 357   (req: <= 3)
Antibodies: 596   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2028.74   (req: >= 5)
Gene RIFs: 357   (req: > 3)
Antibodies: 596   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 233
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4