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Tbio
CASQ2
Calsequestrin-2

Protein Summary
Description
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease chara ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261448
  • ENSP00000261448
  • ENSG00000118729

Symbol
  • PDIB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.89
biological process
0.88
PubMedID
0.66
tissue
0.52
transcription factor binding site profile
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.1   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.1   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
p_int:  0.999999645
p_ni:  3.55e-7
Data Source:  BioPlex
ASB1
Tdark
Novelty:  0.0931554
p_int:  0.999997594
p_ni:  0.000002403
p_wrong:  3e-9
Score:  0.21
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999993234
p_ni:  0.000006766
Score:  0.16
Data Source:  BioPlex,STRINGDB
FBXW8
Tbio
Novelty:  0.06697145
p_int:  0.999988782
p_ni:  0.000008842
p_wrong:  0.000002376
Data Source:  BioPlex
EPB41L4B
Tbio
Novelty:  0.132572
p_int:  0.99998698
p_ni:  0.000012814
p_wrong:  2.06e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
CUL7
Tbio
Novelty:  0.02183958
p_int:  0.999956174
p_ni:  0.000043826
Data Source:  BioPlex
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.999868691
p_ni:  0.000131309
Score:  0.185
Data Source:  BioPlex,STRINGDB
PRDM10
Tbio
Family:  TF; Epigenetic
Novelty:  0.03463517
p_int:  0.999848645
p_ni:  0.000151355
Data Source:  BioPlex
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.999768207
p_ni:  0.000231792
Data Source:  BioPlex
ZFP91
Tbio
Family:  TF
Novelty:  0.06937322
p_int:  0.999546644
p_ni:  0.000453236
p_wrong:  1.21e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
2
2
89.2
electrocardiography
1
1
20
78
2
2
0
1.1
77.6
left atrial function
2
1
2
59.5
heart function measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
2
89.2
electrocardiography
20
78
0
1.1
77.6
left atrial function
2
59.5
heart function measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calsequestrin 2
VGNC:5002
457150
Macaque
calsequestrin 2
712373
Mouse
MGI:1309469
12373
Rat
RGD:2276
29209
Dog
calsequestrin 2
VGNC:38739
483134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calsequestrin 2
Macaque
calsequestrin 2
Mouse
Rat
Dog
calsequestrin 2
Publication Statistics
PubMed Score 131.10
PubMed score by year
PubTator Score 75.68
PubTator score by year
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Related Publications
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PMID
Year
Title