Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase ...more
- ENST00000333868
- ENSP00000330237
- ENSG00000132906
- ENST00000348549
- ENSP00000255256
- ENST00000375890
- ENSP00000365051
- MCH6
- MCH6
- APAF3
- APAF-3
- PPP1R56
- ICE-LAP6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
kinase | 0.99 | ||
protein domain | 0.99 | ||
hub protein | 0.95 | ||
biological process | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3708.25 (req: < 5)
Gene RIFs: 227 (req: <= 3)
Antibodies: 1672 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3708.25 (req: >= 5)
Gene RIFs: 227 (req: > 3)
Antibodies: 1672 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (283)
BIRC8
Novelty: 0.05142518
p_int: 0.916097331
p_wrong: 0.083902669
Score: 0.965
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (107)
Reactome (25)
KEGG (31)
PathwayCommons (17)
WikiPathways (34)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | AKT phosphorylates targets in the cytosol | ||||
Reactome | Activation of caspases through apoptosome-mediated cleavage | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic factor-mediated response | ||||
Reactome | Caspase activation via Dependence Receptors in the absence of ligand | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
AKT phosphorylates targets in the cytosol | ||||
Activation of caspases through apoptosome-mediated cleavage | ||||
Apoptosis | ||||
Apoptotic factor-mediated response | ||||
Caspase activation via Dependence Receptors in the absence of ligand | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (8)
Components (6)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 7 | 7 | 6 | 8.2 | 94.6 | ||||
urate measurement | 3 | 4 | 4 | 92.5 | |||||
1 | 6 | 0 | 1.6 | 91.9 | |||||
creatinine measurement | 4 | 4 | 4 | 84.3 | |||||
body mass index | 2 | 2 | 2 | 49.4 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 6 | 8.2 | 94.6 | ||||
urate measurement | 4 | 92.5 | |||||
0 | 1.6 | 91.9 | |||||
creatinine measurement | 4 | 84.3 | |||||
body mass index | 2 | 49.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | caspase 9 | 694544 | ||||||
Mouse | MGI:1277950 | 12371 | ||||||
Rat | RGD:61867 | 58918 | ||||||
Dog | caspase 9 | 487432 | ||||||
Horse | caspase 9 | VGNC:50673 | 100054331 | |||||
Publication Statistics
PubMed Score 3708.25
PubMed score by year
PubTator Score 3273.28
PubTator score by year
Related Publications
Text Mined References (335)
GeneRif Annotations (227)
Items per page:
0 of 0
PMID | Year | Title |
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