Tchem CASP7 Caspase-7

Protein Summary

Description

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• P55210
• B4DQU7
• B5BU45
• D3DRB8
• Q13364
• Q53YD5
• Q5SVL0
• Q5SVL3
• Q96BA0
• CASP-7

Gene Name

• CASP7

Ensembl ID

• ENST00000345633
• ENSP00000298701
• ENSG00000165806
• ENST00000369315
• ENSP00000358321
• ENST00000369318
• ENSP00000358324
• ENST00000369331
• ENSP00000358337
• ENST00000452490
• ENSP00000398107
• ENST00000614447
• ENSP00000478285
• ENST00000621345
• ENSP00000480584
• ENST00000621607
• ENSP00000478999

Symbol

• MCH3
• MCH3
• CMH-1
• LICE2
• CASP-7
• ICE-LAP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
virus perturbation	1
hub protein	0.88
protein domain	0.85
gene perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-7

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-7

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.48   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 991   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.48   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 991   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 329

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0