Protein Summary
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
- ENST00000265164
- ENSP00000265164
- ENSG00000138794
- ENST00000352981
- ENSP00000285333
- MCH2
- MCH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.91 | ||
transcription factor perturbation | 0.88 | ||
protein domain | 0.85 | ||
hub protein | 0.79 | ||
gene perturbation | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 389.23 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 1062 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 389.23 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 1062 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 171
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (171)
Protein-Protein Interactions (109)
Nearest Tclin Targets
Pathways (79)
Reactome (12)
KEGG (1)
PathwayCommons (7)
WikiPathways (59)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Breakdown of the nuclear lamina | ||||
Reactome | Caspase-mediated cleavage of cytoskeletal proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Breakdown of the nuclear lamina | ||||
Caspase-mediated cleavage of cytoskeletal proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 1 | 4 | 84.5 | |||||
apolipoprotein A 1 measurement | 2 | 2 | 3 | 84.5 | |||||
3 | 3 | 0 | 1.2 | 81.4 | |||||
atrophic macular degeneration | 1 | 2 | 0 | 2.4 | 71.5 | ||||
2 | 2 | 0 | 1.3 | 71.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 84.5 | |||||
apolipoprotein A 1 measurement | 3 | 84.5 | |||||
0 | 1.2 | 81.4 | |||||
atrophic macular degeneration | 0 | 2.4 | 71.5 | ||||
0 | 1.3 | 71.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | caspase 6 | 698788 | ||||||
Mouse | MGI:1312921 | 12368 | ||||||
Rat | RGD:70967 | 83584 | ||||||
Dog | caspase 6 | 487899 | ||||||
Horse | caspase 6 | VGNC:16069 | 100072861 | |||||
Publication Statistics
PubMed Score 389.23
PubMed score by year
PubTator Score 348.68
PubTator score by year
Related Publications
Text Mined References (123)
GeneRif Annotations (59)
Items per page:
0 of 0
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