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Tchem
CASP6
Caspase-6

Protein Summary
Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265164
  • ENSP00000265164
  • ENSG00000138794
  • ENST00000352981
  • ENSP00000285333

Symbol
  • MCH2
  • MCH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.91
transcription factor perturbation
0.88
protein domain
0.85
hub protein
0.79
gene perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.23   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 1062   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 389.23   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 1062   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 171
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (109)
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  STRINGDB
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
Score:  0.991
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.982
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.971
Data Source:  STRINGDB
LMNA
Tbio
Novelty:  0.00046972
Score:  0.97
Data Source:  Reactome,STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.97
Data Source:  STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.964
Data Source:  Reactome,STRINGDB
SATB1
Tbio
Family:  TF
Novelty:  0.00434577
Score:  0.957
Data Source:  Reactome,STRINGDB
LMNB2
Tbio
Novelty:  0.0019221
Score:  0.95
Data Source:  STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Breakdown of the nuclear lamina
Reactome
Caspase-mediated cleavage of cytoskeletal proteins
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Breakdown of the nuclear lamina
Caspase-mediated cleavage of cytoskeletal proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
84.5
apolipoprotein A 1 measurement
2
2
3
84.5
3
3
0
1.2
81.4
atrophic macular degeneration
1
2
0
2.4
71.5
2
2
0
1.3
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
84.5
apolipoprotein A 1 measurement
3
84.5
0
1.2
81.4
atrophic macular degeneration
0
2.4
71.5
0
1.3
71.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
caspase 6
698788
Mouse
MGI:1312921
12368
Rat
RGD:70967
83584
Dog
caspase 6
487899
Horse
caspase 6
VGNC:16069
100072861
Species
Name
OMA
EggNOG
Inparanoid
Macaque
caspase 6
Mouse
Rat
Dog
caspase 6
Horse
caspase 6
Publication Statistics
PubMed Score 389.23
PubMed score by year
PubTator Score 348.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title