Tchem CASP1 Caspase-1

Protein Summary

Description

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P29466
• B5MDZ1
• Q53EY6
• Q6DMQ1
• Q6GSS3
• Q6PI75
• Q9UCN3
• CASP-1

Gene Name

• CASP1

Ensembl ID

• ENST00000353247
• ENSP00000344132
• ENSG00000137752
• ENST00000436863
• ENSP00000410076
• ENST00000446369
• ENSP00000403260
• ENST00000525825
• ENSP00000434779
• ENST00000526568
• ENSP00000434250
• ENST00000531166
• ENSP00000434303
• ENST00000533400
• ENSP00000433138
• ENST00000534497
• ENSP00000436875

Symbol

• IL1BC
• IL1BCE
• ICE
• P45
• IL1BC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.99
biological process	0.94
chemical	0.93
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Caspase-1

Protein / Enzyme Modulator / Protease Inhibitor / Caspase-1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Caspase-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3266.99   (req: < 5)

Gene RIFs: 229   (req: <= 3)

Antibodies: 1028   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3266.99   (req: >= 5)

Gene RIFs: 229   (req: > 3)

Antibodies: 1028   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 406

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1