Protein Summary
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neu ...more
- ENST00000264645
- ENSP00000264645
- ENSG00000108349
- MLN51
- BTZ
- MLN51
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
ligand (protein) perturbation | 0.96 | ||
virus perturbation | 0.94 | ||
kinase perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
histone modification site profile | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.75 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 261 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.75 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 261 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (362)
UPF3A
Novelty: 0.01431609
p_int: 0.999962762
p_ni: 0.000037238
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PYM1
Novelty: 0.04117785
p_int: 0.999682994
p_ni: 0.000317006
Score: 0.956
Data Source: BioPlex,STRINGDB
PNN
Novelty: 0.01395394
p_int: 0.999334995
p_ni: 0.000665005
Score: 0.821
Data Source: BioPlex,STRINGDB
SNIP1
Novelty: 0.01865867
p_int: 0.998544002
p_ni: 0.001455998
Score: 0.519
Data Source: BioPlex,STRINGDB
LARP4B
Novelty: 0.11363794
p_int: 0.997665773
p_ni: 0.002334177
p_wrong: 5e-8
Data Source: BioPlex
ELAVL2
Novelty: 0.00370708
p_int: 0.996916555
p_ni: 0.003083444
Score: 0.92
Data Source: BioPlex,STRINGDB
GSPT2
Family: Enzyme
Novelty: 0.08140512
p_int: 0.992365325
p_ni: 0.007634658
p_wrong: 1.7e-8
Score: 0.916
Data Source: BioPlex,STRINGDB
MCRIP2
Novelty: 1.50465727
p_int: 0.988254228
p_ni: 0.011745761
p_wrong: 1.2e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (18)
Reactome (16)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 1 | 4 | 75.6 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 69.6 | |||||
1 | 1 | 0 | 1.1 | 59.5 | |||||
mathematical ability | 2 | 1 | 2 | 49.5 | |||||
mitochondrial DNA measurement | 1 | 1 | 1 | 48.5 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 75.6 | |||||
high density lipoprotein cholesterol measurement | 2 | 69.6 | |||||
0 | 1.1 | 59.5 | |||||
mathematical ability | 2 | 49.5 | |||||
mitochondrial DNA measurement | 1 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cancer susceptibility 3 | 454646 | ||||||
Mouse | MGI:2179723 | 192160 | ||||||
Rat | RGD:628766 | 259170 | ||||||
Dog | CASC3, exon junction complex subunit | VGNC:54699 | 480528 | |||||
Horse | CASC3, exon junction complex subunit | VGNC:54696 | 100067814 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cancer susceptibility 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | CASC3, exon junction complex subunit | |||||
Horse | CASC3, exon junction complex subunit | |||||
Publication Statistics
PubMed Score 22.75
PubMed score by year
PubTator Score 24.11
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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