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Tbio
CARTPT
Cocaine- and amphetamine-regulated transcript protein

Protein Summary
Description
Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides. These peptides play a role in appetite, energy balance, maintenance of body weight, reward and addiction, and the stress response. Expression of a similar gene transcript in rodents is upregulated following administration of cocaine and amphetamine. Mutations in this gene are associated with susceptibility to obesity in humans. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296777
  • ENSP00000296777
  • ENSG00000164326

Symbol
  • CART
  • CART
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
cell type or tissue
0.77
gene perturbation
0.6
biological term
0.57
PubMedID
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.99   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.99   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
ORC3
Tbio
Novelty:  0.03409802
p_int:  0.999999998
p_ni:  2e-9
Data Source:  BioPlex
ORC2
Tbio
Novelty:  0.11963517
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.99999993
p_ni:  7e-8
Data Source:  BioPlex
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
p_int:  0.999972281
p_ni:  0.000027718
p_wrong:  1e-9
Data Source:  BioPlex
LRWD1
Tbio
Novelty:  0.09049722
p_int:  0.999831049
p_ni:  0.000168951
p_wrong:  1e-9
Data Source:  BioPlex
RBCK1
Tbio
Novelty:  0.02760333
p_int:  0.999523783
p_ni:  0.000260632
p_wrong:  0.000215586
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.998890321
p_ni:  0.001109679
Score:  0.155
Data Source:  BioPlex,STRINGDB
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.998582546
p_ni:  0.0007412
p_wrong:  0.000676254
Data Source:  BioPlex
RHBDD1
Tbio
Family:  Enzyme
Novelty:  0.10354568
p_int:  0.998420671
p_ni:  0.001490764
p_wrong:  0.000088565
Data Source:  BioPlex
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
p_int:  0.998089884
p_ni:  0.00168422
p_wrong:  0.000225896
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Find Similar Targets
Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Circadian rhythm related genes
WikiPathways
G13 Signaling Pathway
WikiPathways
G13 Signaling Pathway
WikiPathways
Follicle Stimulating Hormone (FSH) signaling pathway
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
Name
Explore in Pharos
Explore in Source
Circadian rhythm related genes
G13 Signaling Pathway
G13 Signaling Pathway
Follicle Stimulating Hormone (FSH) signaling pathway
AMP-activated Protein Kinase (AMPK) Signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
49.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
49.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CART prepropeptide
VGNC:3929
741390
Macaque
CART prepropeptide
701350
Mouse
MGI:1351330
27220
Rat
RGD:2272
29131
Dog
CART prepropeptide
VGNC:38727
610236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CART prepropeptide
Macaque
CART prepropeptide
Mouse
Rat
Dog
CART prepropeptide
Publication Statistics
PubMed Score 412.99
PubMed score by year
PubTator Score 518.54
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title