CARNS1
Carnosine synthase 1
Protein Summary
Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system, respectively (Drozak et al., 2010 [PubMed 20097752]).[supplied by OMIM, Apr 2010]
- ENST00000307823
- ENSP00000308268
- ENSG00000172508
- ENST00000445895
- ENSP00000389009
- ENST00000531040
- ENSP00000431670
- ATPGD1
- KIAA1394
- ATPGD1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
gene perturbation | 0.62 | ||
cell type or tissue | 0.61 | ||
cellular component | 0.51 | ||
pathway | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.76 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.76 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0