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Tbio
CARNS1
Carnosine synthase 1

Protein Summary
Description
Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. CARNS1 (EC 6.3.2.11), a member of the ATP-grasp family of ATPases, catalyzes the formation of carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine), which are found mainly in skeletal muscle and the central nervous system, respectively (Drozak et al., 2010 [PubMed 20097752]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307823
  • ENSP00000308268
  • ENSG00000172508
  • ENST00000445895
  • ENSP00000389009
  • ENST00000531040
  • ENSP00000431670

Symbol
  • ATPGD1
  • KIAA1394
  • ATPGD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
gene perturbation
0.62
cell type or tissue
0.61
cellular component
0.51
pathway
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
CNDP1
Tbio
Family:  Enzyme
Novelty:  0.0102642
Score:  0.97
Data Source:  STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
Score:  0.969
Data Source:  STRINGDB
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
Score:  0.967
Data Source:  STRINGDB
CNDP2
Tbio
Family:  Enzyme
Novelty:  0.00157228
Score:  0.954
Data Source:  STRINGDB
ALDH3B2
Tbio
Family:  Enzyme
Novelty:  0.08791168
Score:  0.934
Data Source:  STRINGDB
ALDH9A1
Tbio
Family:  Enzyme
Novelty:  0.01688006
Score:  0.922
Data Source:  STRINGDB
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
Score:  0.912
Data Source:  STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
Score:  0.911
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.909
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.905
Data Source:  STRINGDB
Pathways (7)
Histidine catabolism (R-HSA-70921)

Click on a row in the table to change the structure displayed.

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Histidine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Histidine catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
3
3
94.9
body height
2
2
2
94.5
mean corpuscular volume
2
3
3
94
mean corpuscular hemoglobin concentration
2
2
2
89
IGF-1 measurement
1
2
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
3
94.9
body height
2
94.5
mean corpuscular volume
3
94
mean corpuscular hemoglobin concentration
2
89
IGF-1 measurement
2
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnosine synthase 1
VGNC:3193
451368
Macaque
carnosine synthase 1
712485
Mouse
MGI:2147595
107239
Rat
RGD:1308234
309150
Horse
carnosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:29268]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnosine synthase 1
Macaque
carnosine synthase 1
Mouse
Rat
Horse
carnosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:29268]
Publication Statistics
PubMed Score 13.82
PubMed score by year
PubTator Score 2.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title