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Tbio
CARNMT1
Carnosine N-methyltransferase

Protein Summary
Description
N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376834
  • ENSP00000366030
  • ENSG00000156017

Symbol
  • C9orf41
  • C9orf41
  • UPF0586
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
RNF113A
Tbio
Novelty:  0.08315032
p_int:  1
Score:  0.231
Data Source:  BioPlex,STRINGDB
RYDEN
Tdark
Novelty:  0.17308437
p_int:  0.999999217
p_ni:  7.83e-7
Data Source:  BioPlex
DTL
Tbio
Novelty:  0.01659105
p_int:  0.99999915
p_ni:  8.5e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999999105
p_ni:  8.95e-7
Data Source:  BioPlex
MKRN2
Tbio
Family:  Enzyme
Novelty:  0.14061051
p_int:  0.99998676
p_ni:  0.00001324
Score:  0.307
Data Source:  BioPlex,STRINGDB
ZBTB2
Tbio
Family:  TF
Novelty:  0.12299559
p_int:  0.999974774
p_ni:  0.000003749
p_wrong:  0.000021477
Data Source:  BioPlex
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.999954894
p_ni:  0.000045106
Score:  0.152
Data Source:  BioPlex,STRINGDB
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.999948462
p_ni:  0.000051538
Data Source:  BioPlex
ZBTB25
Tbio
Family:  TF
Novelty:  0.0068423
p_int:  0.999888036
p_ni:  2.52e-7
p_wrong:  0.000111712
Score:  0.198
Data Source:  BioPlex,STRINGDB
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
p_int:  0.999822129
p_ni:  0.000177871
Data Source:  BioPlex
Pathways (5)
Histidine catabolism (R-HSA-70921)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Histidine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Histidine catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
magnesium measurement
2
2
1
5.3
64.4
magnesium:creatinine ratio measurement
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
magnesium measurement
1
5.3
64.4
magnesium:creatinine ratio measurement
1
57.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carnosine N-methyltransferase 1
VGNC:13858
472958
Mouse
MGI:1914633
67383
Rat
RGD:1311863
293871
Dog
carnosine N-methyltransferase 1
VGNC:38725
476320
Horse
carnosine N-methyltransferase 1
VGNC:16060
100064023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carnosine N-methyltransferase 1
Mouse
Rat
Dog
carnosine N-methyltransferase 1
Horse
carnosine N-methyltransferase 1
Publication Statistics
PubMed Score 3.75
PubMed score by year
PubTator Score 2.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title