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Tbio
CARD6
Caspase recruitment domain-containing protein 6

Protein Summary
Description
May be involved in apoptosis. This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254691
  • ENSP00000254691
  • ENSG00000132357

Symbol
  • CINCIN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
tissue sample
0.62
cell line
0.59
cell type or tissue
0.5
tissue
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
RIPK2
Tchem
Family:  Kinase
Novelty:  0.00574043
Score:  0.989
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.761
Data Source:  STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
Score:  0.72
Data Source:  STRINGDB
NOD1
Tchem
Novelty:  0.00241763
Score:  0.659
Data Source:  STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
Score:  0.656
Data Source:  STRINGDB
C8B
Tbio
Novelty:  0.00873524
Score:  0.633
Data Source:  STRINGDB
TTC33
Tdark
Novelty:  0.31237949
Score:  0.56
Data Source:  STRINGDB
NLRP1
Tbio
Novelty:  0.00441627
Score:  0.537
Data Source:  STRINGDB
FASTKD2
Tbio
Family:  Enzyme
Novelty:  0.12614412
Score:  0.519
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.5
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
0
1.3
89.7
mean corpuscular hemoglobin concentration
1
1
1
54.4
1
1
0
1.2
52
reticulocyte measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
89.7
mean corpuscular hemoglobin concentration
1
54.4
0
1.2
52
reticulocyte measurement
1
47.7
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase recruitment domain family member 6
VGNC:3928
461902
Macaque
caspase recruitment domain family member 6
695781
Mouse
MGI:3032959
239319
Rat
RGD:1305805
294770
Dog
caspase recruitment domain family member 6
VGNC:38717
100688481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase recruitment domain family member 6
Macaque
caspase recruitment domain family member 6
Mouse
Rat
Dog
caspase recruitment domain family member 6
Publication Statistics
PubMed Score 14.40
PubMed score by year
PubTator Score 6.94
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title