CARD11
Caspase recruitment domain-containing protein 11
Protein Summary
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Whe ...more
- ENST00000396946
- ENSP00000380150
- ENSG00000198286
- CARMA1
- PPBL
- BENTA
- BIMP3
- IMD11
- CARMA1
- IMD11A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.9 | ||
cell type or tissue | 0.78 | ||
kinase | 0.72 | ||
tissue sample | 0.63 | ||
biological term | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 169.78 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 289 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 169.78 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 289 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (126)
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (26)
Reactome (12)
KEGG (3)
PathwayCommons (8)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of NF-kappaB in B cells | ||||
Reactome | Adaptive Immune System | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Reactome | Downstream TCR signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of NF-kappaB in B cells | ||||
Adaptive Immune System | ||||
C-type lectin receptors (CLRs) | ||||
CLEC7A (Dectin-1) signaling | ||||
Downstream TCR signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (2)
Components (7)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 8 | 9 | 97.2 | |||||
eosinophil count | 3 | 4 | 5 | 90.2 | |||||
BMI-adjusted waist circumference | 2 | 5 | 5 | 81.1 | |||||
platelet count | 2 | 2 | 2 | 75.4 | |||||
2 | 2 | 0 | 1.1 | 70.8 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 9 | 97.2 | |||||
eosinophil count | 5 | 90.2 | |||||
BMI-adjusted waist circumference | 5 | 81.1 | |||||
platelet count | 2 | 75.4 | |||||
0 | 1.1 | 70.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | caspase recruitment domain family member 11 | VGNC:4292 | 463235 | |||||
Mouse | MGI:1916978 | 108723 | ||||||
Dog | caspase recruitment domain family member 11 | VGNC:38714 | 489887 | |||||
Horse | caspase recruitment domain family member 11 | VGNC:16053 | 100058981 | |||||
Cow | caspase recruitment domain family member 11 | VGNC:26761 | 515377 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | caspase recruitment domain family member 11 | |||||
Mouse | ||||||
Dog | caspase recruitment domain family member 11 | |||||
Horse | caspase recruitment domain family member 11 | |||||
Cow | caspase recruitment domain family member 11 | |||||
Publication Statistics
PubMed Score 169.78
PubMed score by year
PubTator Score 118.65
PubTator score by year
Related Publications
Text Mined References (89)
GeneRif Annotations (64)
Items per page:
0 of 0
PMID | Year | Title |
|---|