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Tbio
CARD10
Caspase recruitment domain-containing protein 10

Protein Summary
Description
Activates NF-kappa-B via BCL10 and IKK. The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251973
  • ENSP00000251973
  • ENSG00000100065
  • ENST00000403299
  • ENSP00000384570
  • ENST00000406271
  • ENSP00000385799

Symbol
  • CARMA3
  • BIMP1
  • CARMA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
disease perturbation
0.74
histone modification site profile
0.73
interacting protein
0.73
transcription factor
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.56   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.56   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
GFOD1
Tdark
Family:  Enzyme
Novelty:  0.35031766
p_int:  0.99999062
p_ni:  5.2e-8
p_wrong:  0.000009327
Score:  0.209
Data Source:  BioPlex,STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
p_int:  0.999916411
p_ni:  0.00000814
p_wrong:  0.000075448
Score:  0.214
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.993987908
p_ni:  4.74e-7
p_wrong:  0.006011618
Score:  0.189
Data Source:  BioPlex,STRINGDB
BCL10
Tbio
Novelty:  0.00253704
Score:  0.99
Data Source:  STRINGDB
MALT1
Tchem
Novelty:  0.00367231
Score:  0.974
Data Source:  STRINGDB
CARD11
Tbio
Family:  Enzyme
Novelty:  0.00716457
Score:  0.911
Data Source:  STRINGDB
CARD14
Tbio
Family:  Enzyme
Novelty:  0.01146691
Score:  0.852
Data Source:  STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.845
Data Source:  STRINGDB
PRKCQ
Tchem
Family:  Kinase
Novelty:  0.00562719
Score:  0.839
Data Source:  STRINGDB
GUK1
Tbio
Family:  Kinase
Novelty:  0.00475753
Score:  0.743
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
2
3
3
96.6
cup-to-disc ratio measurement
3
3
4
94.5
optic disc area measurement
3
3
5
93.2
blood protein measurement
1
1
1
71.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
3
96.6
cup-to-disc ratio measurement
4
94.5
optic disc area measurement
5
93.2
blood protein measurement
1
71.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2146012
105844
Rat
RGD:1304949
315120
Dog
caspase recruitment domain family member 10
VGNC:38713
481268
Cow
caspase recruitment domain family member 10
VGNC:26760
535188
Opossum
caspase recruitment domain family member 10
100025552
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
caspase recruitment domain family member 10
Cow
caspase recruitment domain family member 10
Opossum
caspase recruitment domain family member 10
Publication Statistics
PubMed Score 74.56
PubMed score by year
PubTator Score 28.34
PubTator score by year
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Related Publications
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PMID
Year
Title