Tbio CAPN8 Calpain-8

Protein Summary

Description

Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).

Uniprot Accession IDs

• A6NHC0
• B2RXL2

Gene Name

• CAPN8

Ensembl ID

• ENST00000366872
• ENSP00000355837
• ENSG00000203697

Symbol

• NCL2
• nCL-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
virus perturbation	0.79
tissue sample	0.68
gene perturbation	0.56
cellular component	0.5

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Calpain-8

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calpain-8

Protein / Calcium-binding Protein / Annexin / Calpain-8

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Calpain-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.9   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.9   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0