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Tbio
CAPN7
Calpain-7

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease. Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253693
  • ENSP00000253693
  • ENSG00000131375

Symbol
  • PALBH
  • PALBH
  • CALPAIN7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
virus perturbation
0.76
protein domain
0.73
kinase perturbation
0.71
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.86   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.86   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CAPNS1
Tbio
Novelty:  0.00954566
Score:  0.967
Data Source:  STRINGDB
CAPNS2
Tbio
Novelty:  0.45658116
Score:  0.944
Data Source:  STRINGDB
CAST
Tbio
Novelty:  0.00099404
Score:  0.939
Data Source:  STRINGDB
OXNAD1
Tdark
Family:  Enzyme
Novelty:  1.38777329
Score:  0.8
Data Source:  STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.77
Data Source:  STRINGDB
IST1
Tbio
Novelty:  0.01780503
Score:  0.767
Data Source:  STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.763
Data Source:  STRINGDB
XIRP1
Tbio
Novelty:  0.0599323
Score:  0.75
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.67
Data Source:  STRINGDB
CTSB
Tchem
Family:  Enzyme
Novelty:  0.00026238
Score:  0.665
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Degradation of the extracellular matrix (R-HSA-1474228)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 7
VGNC:1752
460202
Macaque
calpain 7
693743
Mouse
MGI:1338030
12339
Rat
RGD:1304855
306260
Dog
calpain 7
VGNC:38707
477062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 7
Macaque
calpain 7
Mouse
Rat
Dog
calpain 7
Publication Statistics
PubMed Score 30.86
PubMed score by year
PubTator Score 11.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title