Tbio CAPN6 Calpain-6

Protein Summary

Description

Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q9Y6Q1
• D3DUY7
• Q9UEQ1
• Q9UJA8

Gene Name

• CAPN6

Ensembl ID

• ENST00000324068
• ENSP00000317214
• ENSG00000077274

Symbol

• CALPM
• CANPX
• CANPX
• CAPNX
• CalpM
• DJ914P14.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
microRNA	0.84
disease perturbation	0.62
gene perturbation	0.61
PubMedID	0.58

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Calpain-6

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calpain-6

Protein / Calcium-binding Protein / Annexin / Calpain-6

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Calpain-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.61   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.61   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0