Protein Summary
Calcium-regulated non-lysosomal thiol-protease. Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3. [provided by RefSeq, Jul 2008]
- ENST00000278559
- ENSP00000278559
- ENSG00000149260
- ENST00000529629
- ENSP00000432332
- ENST00000531028
- ENSP00000467244
- ENST00000648180
- ENSP00000498132
- NCL3
- VRNI
- ADNIV
- HTRA3
- nCL-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
kinase perturbation | 0.81 | ||
disease perturbation | 0.79 | ||
histone modification site profile | 0.76 | ||
transcription factor binding site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.8 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 229 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.8 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 229 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (51)
PHTF1
Novelty: 0.05632054
p_int: 0.99800849
p_ni: 0.000006058
p_wrong: 0.001985452
Score: 0.485
Data Source: BioPlex,STRINGDB
STIP1
Novelty: 0.00590952
p_int: 0.858261134
p_ni: 0.141738866
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (67)
Reactome (2)
PathwayCommons (1)
WikiPathways (64)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | calpain 5 | 698077 | ||||||
Mouse | MGI:1100859 | 12337 | ||||||
Rat | RGD:620084 | 171495 | ||||||
Dog | calpain 5 | VGNC:38705 | 485175 | |||||
Horse | calpain 5 | VGNC:16041 | 100063478 | |||||
Publication Statistics
PubMed Score 43.80
PubMed score by year
PubTator Score 46.88
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (19)
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