Protein Summary
Calcium-regulated non-lysosomal thiol-protease. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
- ENST00000337571
- ENSP00000336840
- ENSG00000092529
- ENST00000349748
- ENSP00000183936
- ENST00000356316
- ENSP00000348667
- ENST00000357568
- ENSP00000350181
- ENST00000397163
- ENSP00000380349
- ENST00000397200
- ENSP00000380384
- ENST00000397204
- ENSP00000380387
- ENST00000569136
- ENSP00000455254
- CANP3
- CANPL3
- NCL1
- p94
- CANP3
- LGMD2
- nCL-1
- CANPL3
- LGMD2A
- LGMDD4
- LGMDR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
protein domain | 0.99 | ||
molecular function | 0.88 | ||
disease perturbation | 0.87 | ||
cellular component | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.77 (req: < 5)
Gene RIFs: 80 (req: <= 3)
Antibodies: 166 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 347.77 (req: >= 5)
Gene RIFs: 80 (req: > 3)
Antibodies: 166 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (98)
Nearest Tclin Targets
Pathways (23)
Reactome (2)
PathwayCommons (1)
WikiPathways (20)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (10)
Components (9)
Processes (29)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 8 | 4 | 9 | 7 | 94.2 | ||||
monocyte percentage of leukocytes | 2 | 1 | 2 | 82.1 | |||||
IGF-1 measurement | 1 | 1 | 1 | 78.4 | |||||
serum albumin measurement | 1 | 1 | 1 | 76.7 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 2 | 69.6 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 9 | 7 | 94.2 | ||||
monocyte percentage of leukocytes | 2 | 82.1 | |||||
IGF-1 measurement | 1 | 78.4 | |||||
serum albumin measurement | 1 | 76.7 | |||||
high density lipoprotein cholesterol measurement | 2 | 69.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | calpain 3 | VGNC:11838 | 100611209 | |||||
Macaque | calpain 3 | 707913 | ||||||
Mouse | MGI:107437 | 12335 | ||||||
Rat | RGD:2269 | 29155 | ||||||
Dog | calpain 3 | VGNC:38704 | 100856545 | |||||
Publication Statistics
PubMed Score 347.77
PubMed score by year
PubTator Score 293.35
PubTator score by year
Related Publications
Text Mined References (116)
GeneRif Annotations (80)
Items per page:
0 of 0
PMID | Year | Title |
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