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Tchem
CAPN2
Calpain-2 catalytic subunit

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 200 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295006
  • ENSP00000295006
  • ENSG00000162909
  • ENST00000433674
  • ENSP00000413158

Symbol
  • CANPL2
  • CANP2
  • mCANP
  • CANPL2
  • CANPml
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.97
transcription factor perturbation
0.97
disease perturbation
0.93
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.87   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 381   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.87   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 381   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 125
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (160)
CAST
Tbio
Novelty:  0.00099404
p_int:  0.999986438
p_ni:  0.000013562
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
TUT4
Tbio
Family:  Enzyme
Novelty:  0.03220878
p_int:  0.999964862
p_ni:  0.000018462
p_wrong:  0.000016676
Data Source:  BioPlex
PPIP5K2
Tchem
Family:  Enzyme
Novelty:  0.0284462
p_int:  0.999669555
p_ni:  0.000330438
p_wrong:  7e-9
Data Source:  BioPlex
FAM208A
Tbio
Novelty:  0.17789689
p_int:  0.998487305
p_ni:  0.001512695
Data Source:  BioPlex
SPATA5L1
Tdark
Family:  Enzyme
Novelty:  0.5393372
p_int:  0.997454542
p_ni:  0.002545458
Data Source:  BioPlex
CAPN1
Tchem
Novelty:  0.00252811
p_int:  0.996367444
p_ni:  0.003632556
Score:  0.919
Data Source:  BioPlex,STRINGDB
CAPNS1
Tbio
Novelty:  0.00954566
p_int:  0.996177045
p_ni:  0.003822954
p_wrong:  1e-9
Score:  0.948
Data Source:  BioPlex,Reactome,STRINGDB
CD109
Tbio
Novelty:  0.01280272
p_int:  0.99307205
p_ni:  0.006927929
p_wrong:  2.1e-8
Data Source:  BioPlex
TEDC1
Tdark
Novelty:  0.74182963
p_int:  0.991039037
p_ni:  0.007267128
p_wrong:  0.001693835
Data Source:  BioPlex
WDR36
Tbio
Novelty:  0.02010676
p_int:  0.989664555
p_ni:  0.010335143
p_wrong:  3.02e-7
Data Source:  BioPlex
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
1 – 5 of 13
KDR
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
MET
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
ITGB1
Tclin
Family:  Other
KEGG Distance:  2
Common Pathways:  1
ERBB2
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Pathways (18)
Degradation of the extracellular matrix (R-HSA-1474228)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Disease
Reactome
Extracellular matrix organization
Reactome
Neurodegenerative Diseases
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Disease
Extracellular matrix organization
Neurodegenerative Diseases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
67.7
waist-hip ratio
1
1
1
31.4
alpha-carotene measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
67.7
waist-hip ratio
1
31.4
alpha-carotene measurement
1
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 2
VGNC:6731
457765
Macaque
calpain 2
703047
Mouse
MGI:88264
12334
Rat
RGD:2268
29154
Dog
calpain 2
VGNC:53334
480118
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 2
Macaque
calpain 2
Mouse
Rat
Dog
calpain 2
Publication Statistics
PubMed Score 237.87
PubMed score by year
PubTator Score 286.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title