Tbio CAPN15 Calpain-15

Protein Summary

Description

This gene encodes a protein containing zinc-finger-like repeats and a calpain-like protease domain. The encoded protein may function as a transcription factor, RNA-binding protein, or in protein-protein interactions during visual system development. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75808
• B1B1M4
• Q2KHS2
• Q8WTY9
• Q9BUW0

Gene Name

• CAPN15

Ensembl ID

• ENST00000219611
• ENSP00000219611
• ENSG00000103326

Symbol

• SOLH
• SOLH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
histone modification site profile	0.76
tissue	0.69
cell type or tissue	0.67
tissue sample	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Calpain-15

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calpain-15

Protein / Calcium-binding Protein / Annexin / Calpain-15

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Calpain-15

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.02   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.02   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

• See Interactions on String-DB

HERPUD1

Tbio

Novelty:  0.00793854

p_int:  0.999954222

p_ni:  0.000045778

Score:  0.537

Data Source:  BioPlex,STRINGDB

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.999591501

p_ni:  0.000401878

p_wrong:  0.000006621

Data Source:  BioPlex

UNC119

Tchem

Novelty:  0.00396292

p_int:  0.999476335

p_ni:  0.000517528

p_wrong:  0.000006137

Score:  0.164

Data Source:  BioPlex,STRINGDB

FAM189B

Tbio

Novelty:  0.21064304

p_int:  0.999474634

p_ni:  0.000525366

Data Source:  BioPlex

TBL1Y

Tbio

p_int:  0.999441635

p_ni:  0.000558358

p_wrong:  7e-9

Data Source:  BioPlex

FNDC5

Tbio

Novelty:  0.0015827

p_int:  0.998804046

p_ni:  0.001195954

Score:  0.187

Data Source:  BioPlex,STRINGDB

RNF126

Tbio

Family:  Enzyme

Novelty:  0.08123801

p_int:  0.998647221

p_ni:  0.00135277

p_wrong:  8e-9

Score:  0.254

Data Source:  BioPlex,STRINGDB

FAM189A2

Tdark

Novelty:  0.41335428

p_int:  0.998527102

p_ni:  0.001472875

p_wrong:  2.3e-8

Data Source:  BioPlex

CDH5

Tbio

Novelty:  0.00072649

p_int:  0.991171742

p_ni:  0.008788144

p_wrong:  0.000040113

Score:  0.178

Data Source:  BioPlex,STRINGDB

CAPNS1

Tbio

Novelty:  0.00954566

Score:  0.966

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Degradation of the extracellular matrix (R-HSA-1474228)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (5)

Components (1)

Processes (1)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
calcium-dependent cysteine-type endopeptidase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cysteine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc
peptidase activity	Traceable Author Statement (TAS)	ProtInc
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	2	2	2		92.8
platelet count	EFO_0004309	2	2	2		90.6
reticulocyte measurement	EFO_0010700	2	2	2		85.8
mean reticulocyte volume	EFO_0010701	1	2	2		81.8
reticulocyte count	EFO_0007986	2	1	2		76.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	2		92.8
platelet count	EFO_0004309	2		90.6
reticulocyte measurement	EFO_0010700	2		85.8
mean reticulocyte volume	EFO_0010701	2		81.8
reticulocyte count	EFO_0007986	2		76.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Protease
Reference proteome
Repeat
Thiol protease
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
glucose measurement
heel bone mineral density
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean platelet volume
mean reticulocyte volume
platelet count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	calpain 15		695881
Mouse	calpain 15	MGI:1355075	50817
Rat	calpain 15	RGD:1306514	303000
Dog	calpain 15	VGNC:38703	490097
Horse	calpain 15 [Source:HGNC Symbol;Acc:HGNC:11182]

Species	Name	OMA	EggNOG	Inparanoid
Macaque	calpain 15
Mouse	calpain 15
Rat	calpain 15
Dog	calpain 15
Horse	calpain 15 [Source:HGNC Symbol;Acc:HGNC:11182]

Publication Statistics

PubMed Score 98.02

PubMed score by year

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PubTator Score 5.33

PubTator score by year

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Related Publications

Text Mined References (9)

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10

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PMID	Year	Title