You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
CAPN13
Calpain-13

Protein Summary
Description
Probable non-lysosomal thiol-protease. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295055
  • ENSP00000295055
  • ENSG00000162949
  • ENST00000458085
  • ENSP00000416191
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
protein domain
0.73
phenotype
0.61
disease
0.55
cell type or tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
ZC3H4
Tbio
Novelty:  0.14897433
p_int:  0.999997677
p_ni:  0.0000022
p_wrong:  1.23e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
PPP1R10
Tbio
Family:  Enzyme
Novelty:  0.01119155
p_int:  0.999994262
p_ni:  0.000005737
p_wrong:  1e-9
Score:  0.182
Data Source:  BioPlex,STRINGDB
ATMIN
Tbio
Novelty:  0.07523218
p_int:  0.999962502
p_ni:  0.000037498
Score:  0.331
Data Source:  BioPlex,STRINGDB
SFSWAP
Tdark
Novelty:  0.2236256
p_int:  0.998345184
p_ni:  0.001654808
p_wrong:  7e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
SAFB2
Tbio
Novelty:  0.12354864
p_int:  0.996806663
p_ni:  0.003193337
Score:  0.189
Data Source:  BioPlex,STRINGDB
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.990956636
p_ni:  0.009042939
p_wrong:  4.24e-7
Score:  0.21
Data Source:  BioPlex,STRINGDB
PRRC2A
Tbio
Novelty:  0.01493149
p_int:  0.980841005
p_ni:  0.019158995
Score:  0.187
Data Source:  BioPlex,STRINGDB
SF1
Tbio
Novelty:  0.01538883
p_int:  0.954282459
p_ni:  0.045717541
Score:  0.189
Data Source:  BioPlex,STRINGDB
TJP2
Tbio
Novelty:  0.00446681
p_int:  0.949699609
p_ni:  0.05030039
p_wrong:  1e-9
Data Source:  BioPlex
EWSR1
Tbio
Novelty:  0.00068411
p_int:  0.854608349
p_ni:  0.145391651
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye movement measurement
1
1
1
3.8
1
1
0
1.4
3.2
1
1
0
5.5
1.6
response to levodopa
1
1
0
5.5
1.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye movement measurement
1
3.8
0
1.4
3.2
0
5.5
1.6
response to levodopa
0
5.5
1.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 13
VGNC:180
470345
Macaque
calpain 13
706966
Mouse
MGI:2685789
381122
Rat
RGD:1562682
362701
Dog
calpain 13
VGNC:38701
483024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 13
Macaque
calpain 13
Mouse
Rat
Dog
calpain 13
Publication Statistics
PubMed Score 3.29
PubMed score by year
PubTator Score 2.83
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title