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Tbio
CAPN10
Calpain-10

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270361
  • ENSP00000270361
  • ENSG00000142330
  • ENST00000270364
  • ENSP00000270364
  • ENST00000352879
  • ENSP00000289381
  • ENST00000354082
  • ENSP00000270362
  • ENST00000357048
  • ENSP00000349556
  • ENST00000391983
  • ENSP00000375843
  • ENST00000391984
  • ENSP00000375844
  • ENST00000416591
  • ENSP00000400144

Symbol
  • KIAA1845
  • CANP10
  • NIDDM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.85
protein domain
0.85
disease perturbation
0.79
tissue sample
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.41   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.41   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
CAPNS1
Tbio
Novelty:  0.00954566
Score:  0.966
Data Source:  STRINGDB
CAPNS2
Tbio
Novelty:  0.45658116
Score:  0.94
Data Source:  STRINGDB
CAST
Tbio
Novelty:  0.00099404
Score:  0.94
Data Source:  STRINGDB
RNPEPL1
Tbio
Family:  Enzyme
Novelty:  0.03441194
Score:  0.762
Data Source:  STRINGDB
RNPEP
Tchem
Family:  Enzyme
Novelty:  0.00381273
Score:  0.724
Data Source:  STRINGDB
GPR35
Tchem
Family:  GPCR
Novelty:  0.01188578
Score:  0.711
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.67
Data Source:  STRINGDB
CTSB
Tchem
Family:  Enzyme
Novelty:  0.00026238
Score:  0.658
Data Source:  STRINGDB
KIF1A
Tbio
Novelty:  0.00505209
Score:  0.625
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.593
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
2
4
96.2
platelet count
2
1
2
86.4
3
3
0
1.2
82.6
monocyte count
2
1
2
82
mean corpuscular volume
1
1
1
81.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
96.2
platelet count
2
86.4
0
1.2
82.6
monocyte count
2
82
mean corpuscular volume
1
81.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 10
VGNC:10626
460069
Macaque
calpain 10
716360
Mouse
MGI:1344392
23830
Rat
RGD:69354
63834
Dog
calpain 10
VGNC:38699
607311
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 10
Macaque
calpain 10
Mouse
Rat
Dog
calpain 10
Publication Statistics
PubMed Score 215.41
PubMed score by year
PubTator Score 190.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title