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Tchem
CAPN1
Calpain-1 catalytic subunit

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279247
  • ENSP00000279247
  • ENSG00000014216
  • ENST00000524773
  • ENSP00000434176
  • ENST00000527323
  • ENSP00000431984
  • ENST00000533129
  • ENSP00000431686
  • ENST00000533820
  • ENSP00000435272

Symbol
  • CANPL1
  • CANP
  • muCL
  • CANP1
  • SPG76
  • CANPL1
  • muCANP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.91
biological term
0.87
transcription factor binding site profile
0.81
disease
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.33   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.33   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 471
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (155)
CAST
Tbio
Novelty:  0.00099404
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CD99L2
Tbio
Novelty:  0.11041595
p_int:  0.999999995
p_wrong:  5e-9
Score:  0.277
Data Source:  BioPlex,STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.216
Data Source:  BioPlex,STRINGDB
CD109
Tbio
Novelty:  0.01280272
p_int:  0.999999895
p_ni:  9.6e-8
p_wrong:  9e-9
Data Source:  BioPlex
CAPNS2
Tbio
Novelty:  0.45658116
p_int:  0.999999364
p_ni:  6.36e-7
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
FNTB
Tclin
Family:  Enzyme
Novelty:  0.07434994
p_int:  0.999997312
p_ni:  0.000002688
Score:  0.217
Data Source:  BioPlex,STRINGDB
CAPNS1
Tbio
Novelty:  0.00954566
p_int:  0.999964866
p_ni:  0.000035134
Score:  0.947
Data Source:  BioPlex,Reactome,STRINGDB
CAPN8
Tbio
Novelty:  0.03562561
p_int:  0.99956343
p_ni:  0.00043657
Score:  0.83
Data Source:  BioPlex,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
p_int:  0.999234184
p_ni:  0.000765816
Score:  0.509
Data Source:  BioPlex,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.996367444
p_ni:  0.003632556
Score:  0.919
Data Source:  BioPlex,STRINGDB
Pathways (22)
Degradation of the extracellular matrix (R-HSA-1474228)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Developmental Biology
Reactome
Disease
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Developmental Biology
Disease
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
87.7
1
1
0
1.6
81.6
high density lipoprotein cholesterol measurement
1
1
1
37.7
mean corpuscular hemoglobin concentration
1
1
1
30.9
appendicular lean mass
1
1
1
30.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
87.7
0
1.6
81.6
high density lipoprotein cholesterol measurement
1
37.7
mean corpuscular hemoglobin concentration
1
30.9
appendicular lean mass
1
30.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 1
VGNC:7514
451317
Macaque
calpain 1
716618
Mouse
MGI:88263
12333
Rat
RGD:2267
29153
Dog
calpain 1
VGNC:38698
483745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 1
Macaque
calpain 1
Mouse
Rat
Dog
calpain 1
Publication Statistics
PubMed Score 482.33
PubMed score by year
PubTator Score 235.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title