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Tchem
CAPN1
Calpain-1 catalytic subunit

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279247
  • ENSP00000279247
  • ENSG00000014216
  • ENST00000524773
  • ENSP00000434176
  • ENST00000527323
  • ENSP00000431984
  • ENST00000533129
  • ENSP00000431686
  • ENST00000533820
  • ENSP00000435272

Symbol
  • CANPL1
  • CANP
  • muCL
  • CANP1
  • SPG76
  • CANPL1
  • muCANP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.91
biological term
0.87
transcription factor binding site profile
0.81
disease
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.33   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.33   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 471
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0