CAPN1
Calpain-1 catalytic subunit
Protein Summary
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
- ENST00000279247
- ENSP00000279247
- ENSG00000014216
- ENST00000524773
- ENSP00000434176
- ENST00000527323
- ENSP00000431984
- ENST00000533129
- ENSP00000431686
- ENST00000533820
- ENSP00000435272
- CANPL1
- CANP
- muCL
- CANP1
- SPG76
- CANPL1
- muCANP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
interacting protein | 0.91 | ||
biological term | 0.87 | ||
transcription factor binding site profile | 0.81 | ||
disease | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 482.33 (req: < 5)
Gene RIFs: 145 (req: <= 3)
Antibodies: 520 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 482.33 (req: >= 5)
Gene RIFs: 145 (req: > 3)
Antibodies: 520 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 471
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0