You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CAPG
Macrophage-capping protein

Protein Summary
Description
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263867
  • ENSP00000263867
  • ENSG00000042493
  • ENST00000409670
  • ENSP00000386315
  • ENST00000409724
  • ENSP00000386965
  • ENST00000409921
  • ENSP00000387063

Symbol
  • AFCP
  • MCP
  • MCP
  • AFCP
  • HEL-S-66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
transcription factor perturbation
0.94
interacting protein
0.92
kinase perturbation
0.84
PubMedID
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.46   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.46   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.998609936
p_ni:  0.001390063
Data Source:  BioPlex
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.99600403
p_ni:  0.003989149
p_wrong:  0.000006821
Data Source:  BioPlex
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.993046149
p_ni:  0.006952703
p_wrong:  0.000001148
Score:  0.189
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.988655303
p_ni:  0.011344671
p_wrong:  2.6e-8
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.985467313
p_ni:  0.01453261
p_wrong:  7.7e-8
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.983799112
p_ni:  0.016200885
p_wrong:  3e-9
Score:  0.167
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.91765349
p_ni:  0.08234651
Score:  0.184
Data Source:  BioPlex,STRINGDB
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.892335219
p_ni:  0.107661919
p_wrong:  0.000002862
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.856642355
p_ni:  0.143344427
p_wrong:  0.000013218
Data Source:  BioPlex
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
88.8
2
2
2
80.2
platelet count
1
1
1
68.8
high density lipoprotein cholesterol measurement
2
2
3
59.7
neutrophil count
2
1
2
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
88.8
2
80.2
platelet count
1
68.8
high density lipoprotein cholesterol measurement
3
59.7
neutrophil count
2
34.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
capping actin protein, gelsolin like
VGNC:179
459361
Macaque
capping actin protein, gelsolin like
695288
Mouse
MGI:1098259
12332
Rat
RGD:1311724
297339
Dog
capping actin protein, gelsolin like
VGNC:38697
483082
Species
Name
OMA
EggNOG
Inparanoid
Chimp
capping actin protein, gelsolin like
Macaque
capping actin protein, gelsolin like
Mouse
Rat
Dog
capping actin protein, gelsolin like
Publication Statistics
PubMed Score 23.46
PubMed score by year
PubTator Score 83.39
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title