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Tbio
CAP1
Adenylyl cyclase-associated protein 1

Protein Summary
Description
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340450
  • ENSP00000344832
  • ENSG00000131236
  • ENST00000372792
  • ENSP00000361878
  • ENST00000372797
  • ENSP00000361883
  • ENST00000372798
  • ENSP00000361884
  • ENST00000372802
  • ENSP00000361888
  • ENST00000372805
  • ENSP00000361891

Symbol
  • CAP
  • CAP
  • CAP1-PEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
0.99
transcription factor perturbation
0.97
kinase perturbation
0.96
interacting protein
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.75   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.75   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (233)
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999999992
p_wrong:  8e-9
Score:  0.813
Data Source:  BioPlex,STRINGDB
CAP2
Tbio
Family:  Enzyme
Novelty:  0.1142507
p_int:  0.999999686
p_ni:  3.14e-7
Score:  0.926
Data Source:  BioPlex,STRINGDB
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.999984839
p_ni:  0.000015161
Score:  0.593
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.997529737
p_ni:  0.002470263
Score:  0.619
Data Source:  BioPlex,STRINGDB
TWF2
Tbio
Novelty:  0.0419582
p_int:  0.99618401
p_ni:  0.00381599
Score:  0.921
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.993917646
p_ni:  0.006082354
Score:  0.72
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.993783156
p_ni:  0.006216844
Score:  0.773
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.982200048
p_ni:  0.017799952
Score:  0.782
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.979023385
p_ni:  0.020976615
Score:  0.845
Data Source:  BioPlex,STRINGDB
DNAL4
Tbio
Novelty:  0.15546154
p_int:  0.975534803
p_ni:  0.024465197
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (140)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Hemostasis
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
75.6
hematocrit
2
2
2
70.2
mean corpuscular volume
1
1
1
59
platelet count
1
1
1
33.1
red blood cell distribution width
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
75.6
hematocrit
2
70.2
mean corpuscular volume
1
59
platelet count
1
33.1
red blood cell distribution width
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclase associated actin cytoskeleton regulatory protein 1
VGNC:12950
746432
Macaque
cyclase associated actin cytoskeleton regulatory protein 1
693719
Mouse
MGI:88262
12331
Rat
RGD:620309
64185
Dog
cyclase associated actin cytoskeleton regulatory protein 1
475317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclase associated actin cytoskeleton regulatory protein 1
Macaque
cyclase associated actin cytoskeleton regulatory protein 1
Mouse
Rat
Dog
cyclase associated actin cytoskeleton regulatory protein 1
Publication Statistics
PubMed Score 35.75
PubMed score by year
PubTator Score 137.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title