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Tbio
CAP1
Adenylyl cyclase-associated protein 1

Protein Summary
Description
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340450
  • ENSP00000344832
  • ENSG00000131236
  • ENST00000372792
  • ENSP00000361878
  • ENST00000372797
  • ENSP00000361883
  • ENST00000372798
  • ENSP00000361884
  • ENST00000372802
  • ENSP00000361888
  • ENST00000372805
  • ENSP00000361891

Symbol
  • CAP
  • CAP
  • CAP1-PEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
protein domain
0.99
transcription factor perturbation
0.97
kinase perturbation
0.96
interacting protein
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.73   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.73   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0