Protein Summary
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits wit ...more
- ENST00000247461
- ENSP00000247461
- ENSG00000127022
- ENST00000452673
- ENSP00000391646
- ENST00000504734
- ENSP00000424063
- ENST00000638425
- ENSP00000492372
- ENSG00000283777
- ENST00000638706
- ENSP00000492868
- ENST00000639938
- ENSP00000491760
- CNX
- P90
- IP90
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
drug perturbation | 1 | ||
interacting protein | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1257.35 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 1012 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1257.35 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 1012 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (544)
CD1E
Novelty: 0.00171622
p_int: 0.996536101
p_ni: 0.003463899
Score: 0.18
Data Source: BioPlex,STRINGDB
BRINP2
Novelty: 0.5101917
p_int: 0.980406408
p_ni: 0.019593592
Score: 0.172
Data Source: BioPlex,STRINGDB
GXYLT1
Family: Enzyme
Novelty: 0.39064064
p_int: 0.979873865
p_ni: 0.020126135
Data Source: BioPlex
CHST15
Family: Enzyme
Novelty: 0.03950241
p_int: 0.97975032
p_ni: 0.02024968
Score: 0.181
Data Source: BioPlex,STRINGDB
CHST6
Family: Enzyme
Novelty: 0.01917947
p_int: 0.977266771
p_ni: 0.022733229
Data Source: BioPlex
OGFOD3
Family: Enzyme
Novelty: 0.86903294
p_int: 0.973596245
p_ni: 0.026403755
Data Source: BioPlex
Nearest Tclin Targets
Pathways (27)
Reactome (21)
KEGG (5)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Assembly of Viral Components at the Budding Site | ||||
Reactome | Calnexin/calreticulin cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen Presentation: Folding, assembly and peptide loading of class I MHC | ||||
Asparagine N-linked glycosylation | ||||
Assembly of Viral Components at the Budding Site | ||||
Calnexin/calreticulin cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (6)
Components (20)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 3 | 3 | 81.9 | ||||||
monocyte percentage of leukocytes | 2 | 3 | 3 | 81.9 | ||||||
neutrophil count | 4 | 3 | 4 | 76.5 | ||||||
neutrophil count | 4 | 3 | 4 | 76.5 | ||||||
monocyte count | 2 | 2 | 2 | 75.6 | ||||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 3 | 81.9 | |||||
monocyte percentage of leukocytes | 3 | 81.9 | |||||
neutrophil count | 4 | 76.5 | |||||
neutrophil count | 4 | 76.5 | |||||
monocyte count | 2 | 75.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | calnexin | VGNC:3927 | 462330 | |||||
Macaque | calnexin | 704794 | ||||||
Mouse | MGI:88261 | 12330 | ||||||
Rat | RGD:2266 | 29144 | ||||||
Dog | calnexin | VGNC:38695 | 403908 | |||||
Publication Statistics
PubMed Score 1257.35
PubMed score by year
PubTator Score 450.47
PubTator score by year
Related Publications
Text Mined References (140)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
|---|