Protein Summary
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits wit ...more
- ENST00000247461
- ENSP00000247461
- ENSG00000127022
- ENST00000452673
- ENSP00000391646
- ENST00000504734
- ENSP00000424063
- ENST00000638425
- ENSP00000492372
- ENSG00000283777
- ENST00000638706
- ENSP00000492868
- ENST00000639938
- ENSP00000491760
- CNX
- P90
- IP90
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
drug perturbation | 1 | ||
interacting protein | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1257.35 (req: < 5)
Gene RIFs: 66 (req: <= 3)
Antibodies: 1012 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1257.35 (req: >= 5)
Gene RIFs: 66 (req: > 3)
Antibodies: 1012 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0