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Tbio
CANX
Calnexin

Protein Summary
Description
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247461
  • ENSP00000247461
  • ENSG00000127022
  • ENST00000452673
  • ENSP00000391646
  • ENST00000504734
  • ENSP00000424063
  • ENST00000638425
  • ENSP00000492372
  • ENSG00000283777
  • ENST00000638706
  • ENSP00000492868
  • ENST00000639938
  • ENSP00000491760

Symbol
  • CNX
  • P90
  • IP90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
interacting protein
1
virus perturbation
1
transcription factor perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1257.35   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 1012   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1257.35   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 1012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (544)
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.996536101
p_ni:  0.003463899
Score:  0.18
Data Source:  BioPlex,STRINGDB
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.991025366
p_ni:  0.008974635
Data Source:  BioPlex
P2RX2
Tchem
Family:  IC
Novelty:  0.00241146
p_int:  0.988062811
p_ni:  0.011937189
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.985464211
p_ni:  0.014535789
Data Source:  BioPlex
BRINP2
Tdark
Novelty:  0.5101917
p_int:  0.980406408
p_ni:  0.019593592
Score:  0.172
Data Source:  BioPlex,STRINGDB
GXYLT1
Tdark
Family:  Enzyme
Novelty:  0.39064064
p_int:  0.979873865
p_ni:  0.020126135
Data Source:  BioPlex
CHST15
Tbio
Family:  Enzyme
Novelty:  0.03950241
p_int:  0.97975032
p_ni:  0.02024968
Score:  0.181
Data Source:  BioPlex,STRINGDB
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.977306423
p_ni:  0.022693577
Data Source:  BioPlex
CHST6
Tbio
Family:  Enzyme
Novelty:  0.01917947
p_int:  0.977266771
p_ni:  0.022733229
Data Source:  BioPlex
OGFOD3
Tdark
Family:  Enzyme
Novelty:  0.86903294
p_int:  0.973596245
p_ni:  0.026403755
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
Assembly of Viral Components at the Budding Site
Reactome
Calnexin/calreticulin cycle
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
Assembly of Viral Components at the Budding Site
Calnexin/calreticulin cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
3
81.9
monocyte percentage of leukocytes
2
3
3
81.9
neutrophil count
4
3
4
76.5
neutrophil count
4
3
4
76.5
monocyte count
2
2
2
75.6
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
81.9
monocyte percentage of leukocytes
3
81.9
neutrophil count
4
76.5
neutrophil count
4
76.5
monocyte count
2
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calnexin
VGNC:3927
462330
Macaque
calnexin
704794
Mouse
MGI:88261
12330
Rat
RGD:2266
29144
Dog
calnexin
VGNC:38695
403908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calnexin
Macaque
calnexin
Mouse
Rat
Dog
calnexin
Publication Statistics
PubMed Score 1257.35
PubMed score by year
PubTator Score 450.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title