Tbio CANX Calnexin

Protein Summary

Description

Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018]

Uniprot Accession IDs

• P27824
• B2R5V8
• B4DGP8
• B4E2T8
• D3DWQ3
• D6R9K3

Gene Name

• CANX

Ensembl ID

• ENST00000247461
• ENSP00000247461
• ENSG00000127022
• ENST00000452673
• ENSP00000391646
• ENST00000504734
• ENSP00000424063
• ENST00000638425
• ENSP00000492372
• ENSG00000283777
• ENST00000638706
• ENSP00000492868
• ENST00000639938
• ENSP00000491760

Symbol

• CNX
• P90
• IP90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
drug perturbation	1
interacting protein	1
virus perturbation	1
transcription factor perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Chaperone / Calnexin

Protein / Calcium-binding Protein / Calnexin

DTO Classes

Protein / Chaperone / Calnexin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1257.35   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 1012   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1257.35   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 1012   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0