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Tbio
CANT1
Soluble calcium-activated nucleotidase 1

Protein Summary
Description
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336). This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302345
  • ENSP00000307674
  • ENSG00000171302
  • ENST00000392446
  • ENSP00000376241
  • ENST00000591773
  • ENSP00000467437
  • ENST00000620915
  • ENSP00000477798

Symbol
  • SHAPY
  • DBQD
  • EDM7
  • DBQD1
  • SCAN1
  • SHAPY
  • SCAN-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
transcription factor perturbation
0.74
transcription factor
0.73
tissue
0.72
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.05   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.05   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (207)
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999846468
p_ni:  0.000153532
Data Source:  BioPlex
C16orf58
Tdark
Novelty:  0.34461652
p_int:  0.999098246
p_ni:  0.000900512
p_wrong:  0.000001242
Data Source:  BioPlex
BZW2
Tbio
Novelty:  0.17006204
p_int:  0.998873674
p_ni:  0.001126156
p_wrong:  1.7e-7
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.9980345
p_ni:  0.001965465
p_wrong:  3.5e-8
Data Source:  BioPlex
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
p_int:  0.997474841
p_ni:  0.002524794
p_wrong:  3.65e-7
Data Source:  BioPlex
Q8NFQ8
Tbio
Novelty:  0.08912351
p_int:  0.996346215
p_ni:  0.003653785
Data Source:  BioPlex
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.995205084
p_ni:  0.004794292
p_wrong:  6.23e-7
Score:  0.16
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.995045849
p_ni:  0.004789538
p_wrong:  0.000164613
Data Source:  BioPlex
EPB41L4A
Tbio
Novelty:  0.14551912
p_int:  0.992947104
p_ni:  0.006565965
p_wrong:  0.00048693
Data Source:  BioPlex
TMEM130
Tdark
Novelty:  1.39618601
p_int:  0.955233666
p_ni:  0.035181344
p_wrong:  0.009584989
Data Source:  BioPlex
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
1 – 5 of 14
PDE6A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE2A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6H
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (10)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium activated nucleotidase 1
VGNC:12036
468345
Macaque
calcium activated nucleotidase 1
710935
Mouse
MGI:1923275
76025
Rat
RGD:628743
246272
Dog
calcium activated nucleotidase 1
VGNC:49743
483345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium activated nucleotidase 1
Macaque
calcium activated nucleotidase 1
Mouse
Rat
Dog
calcium activated nucleotidase 1
Publication Statistics
PubMed Score 40.05
PubMed score by year
PubTator Score 148.75
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title