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Tbio
CAND1
Cullin-associated NEDD8-dissociated protein 1

Protein Summary
Description
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000545606
  • ENSP00000442318
  • ENSG00000111530

Symbol
  • KIAA0829
  • TIP120
  • TIP120A
  • TIP120
  • TIP120A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
0.99
transcription factor binding site profile
0.89
disease perturbation
0.79
protein complex
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.27   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.27   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (210)
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.807581529
p_ni:  0.192418471
Data Source:  BioPlex
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.788350239
p_ni:  0.211649761
Score:  0.988
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.779944645
p_ni:  0.220055355
Data Source:  BioPlex
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.999
Data Source:  Reactome,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.999
Data Source:  Reactome,STRINGDB
CUL4B
Tbio
Novelty:  0.0133075
Score:  0.998
Data Source:  Reactome,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
Score:  0.993
Data Source:  Reactome,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.993
Data Source:  Reactome,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
Score:  0.991
Data Source:  STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Iron uptake and transport
Reactome
Metabolism of proteins
Reactome
Neddylation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Iron uptake and transport
Metabolism of proteins
Neddylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
2
35.5
triglyceride measurement
2
2
2
27.8
sex hormone-binding globulin measurement
2
2
2
23.7
systolic blood pressure
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
35.5
triglyceride measurement
2
27.8
sex hormone-binding globulin measurement
2
23.7
systolic blood pressure
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cullin associated and neddylation dissociated 1
716184
Mouse
MGI:1261820
71902
Rat
RGD:620479
117152
Dog
cullin associated and neddylation dissociated 1
VGNC:38694
474437
Horse
cullin associated and neddylation dissociated 1
VGNC:16031
100058333
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cullin associated and neddylation dissociated 1
Mouse
Rat
Dog
cullin associated and neddylation dissociated 1
Horse
cullin associated and neddylation dissociated 1
Publication Statistics
PubMed Score 68.27
PubMed score by year
PubTator Score 47.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title