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Tbio
CAMLG
Calcium signal-modulating cyclophilin ligand

Protein Summary
Description
Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297156
  • ENSP00000297156
  • ENSG00000164615

Symbol
  • CAML
  • CAML
  • GET2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
histone modification site profile
0.84
transcription factor binding site profile
0.8
cellular component
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.07   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.07   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
ASNA1
Tbio
Family:  Enzyme
Novelty:  0.01260233
p_int:  0.999999524
p_ni:  4.76e-7
Score:  0.956
Data Source:  BioPlex,Reactome,STRINGDB
TBC1D15
Tbio
Novelty:  0.11296513
p_int:  0.999992491
p_ni:  0.000007509
Score:  0.188
Data Source:  BioPlex,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.998594988
p_ni:  0.001333893
p_wrong:  0.000071119
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.995777929
p_ni:  0.004222059
p_wrong:  1.2e-8
Data Source:  BioPlex
AGTRAP
Tbio
Novelty:  0.02295361
Score:  0.948
Data Source:  STRINGDB
TNFRSF13B
Tbio
Novelty:  0.00338954
Score:  0.926
Data Source:  STRINGDB
WRB
Tbio
Novelty:  0.01267171
Score:  0.909
Data Source:  Reactome,STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.85
Data Source:  STRINGDB
TMUB1
Tbio
Novelty:  0.11851789
Score:  0.811
Data Source:  STRINGDB
KCNE4
Tbio
Family:  IC
Novelty:  0.04524673
Score:  0.808
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium modulating ligand
VGNC:3926
462352
Mouse
MGI:104728
12328
Rat
RGD:69297
81715
Dog
calcium modulating ligand
VGNC:38687
474684
Horse
calcium modulating ligand
VGNC:16026
100062812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium modulating ligand
Mouse
Rat
Dog
calcium modulating ligand
Horse
calcium modulating ligand
Publication Statistics
PubMed Score 108.07
PubMed score by year
PubTator Score 85.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title