CAMKMT
Calmodulin-lysine N-methyltransferase
Protein Summary
Catalyzes the trimethylation of 'Lys-116' in calmodulin. This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]
- ENST00000378494
- ENSP00000367755
- ENSG00000143919
- ENST00000403853
- ENSP00000385124
- C2orf34
- CLNMT
- Cam
- KMT
- CLNMT
- C2orf34
- CaM KMT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.9 | ||
histone modification site profile | 0.86 | ||
trait | 0.86 | ||
transcription factor perturbation | 0.74 | ||
small molecule perturbation | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 20 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 20 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (127)
COL1A2
Novelty: 0.00048334
p_int: 0.999966698
p_ni: 3.37e-7
p_wrong: 0.000032965
Score: 0.309
Data Source: BioPlex,STRINGDB
CALML3
Novelty: 0.0336689
p_int: 0.998982363
p_ni: 3.41e-7
p_wrong: 0.001017296
Data Source: BioPlex
COL1A1
Novelty: 0.00063584
p_int: 0.994391414
p_ni: 0.005608586
Score: 0.188
Data Source: BioPlex,STRINGDB
SELENBP1
Novelty: 0.00758018
p_int: 0.992285477
p_ni: 0.000001952
p_wrong: 0.007712571
Score: 0.183
Data Source: BioPlex,STRINGDB
SNX6
Novelty: 0.05909848
p_int: 0.983884729
p_ni: 0.016115005
p_wrong: 2.66e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
HECTD1
Family: Enzyme
Novelty: 0.28016112
p_int: 0.92604183
p_ni: 0.07395817
Score: 0.187
Data Source: BioPlex,STRINGDB
FEM1B
Novelty: 0.06746412
p_int: 0.863585938
p_ni: 0.136413783
p_wrong: 2.79e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (10)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Inactivation, recovery and regulation of the phototransduction cascade | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 3 | 4 | 2 | 1 | 82.9 | ||||
body height | 2 | 2 | 2 | 78.7 | |||||
self reported educational attainment | 1 | 1 | 1 | 71.9 | |||||
risk-taking behaviour | 2 | 3 | 3 | 66.2 | |||||
body mass index | 1 | 1 | 1 | 54.4 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 1 | 82.9 | ||||
body height | 2 | 78.7 | |||||
self reported educational attainment | 1 | 71.9 | |||||
risk-taking behaviour | 3 | 66.2 | |||||
body mass index | 1 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | calmodulin-lysine N-methyltransferase | 714211 | ||||||
Mouse | MGI:1920832 | 73582 | ||||||
Rat | RGD:1310453 | 299521 | ||||||
Dog | calmodulin-lysine N-methyltransferase | VGNC:38685 | 474575 | |||||
Cow | calmodulin-lysine N-methyltransferase | VGNC:26727 | 786620 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | calmodulin-lysine N-methyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | calmodulin-lysine N-methyltransferase | |||||
Cow | calmodulin-lysine N-methyltransferase | |||||
Publication Statistics
PubMed Score 262.00
PubMed score by year
PubTator Score 13.19
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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