Tbio CAMKMT Calmodulin-lysine N-methyltransferase

Protein Summary

Description

Catalyzes the trimethylation of 'Lys-116' in calmodulin. This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]

Uniprot Accession IDs

• Q7Z624
• Q4ZG15
• Q53SS6
• Q8N6P5
• Q9H5G8
• CLNMT

Gene Name

• CAMKMT

Ensembl ID

• ENST00000378494
• ENSP00000367755
• ENSG00000143919
• ENST00000403853
• ENSP00000385124

Symbol

• C2orf34
• CLNMT
• Cam
• KMT
• CLNMT
• C2orf34
• CaM KMT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.9
histone modification site profile	0.86
trait	0.86
transcription factor perturbation	0.74
small molecule perturbation	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.02   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 20   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.02   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0